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MAP3K3 — MAPK9
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK9
→
MAP3K3
(directlyIncreases, MAP3K3 Activity, MAPK9 Activity)
Evidence: Summary The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses.
Text-mined interactions from Literome
Deacon et al., J Biol Chem 1999
:
We have examined the
regulation by
MEKK3 of
MAPK kinase 7 ( MKK7 ) and MKK6, two novel MAPK kinases specific for JNK and p38, respectively
Korchnak et al., Cell Signal 2009
:
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (
MAP3K ) that
activates multiple mitogen activated protein kinase (
MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wang et al., J Immunol 2011
(MAP Kinase Signaling System) :
Furthermore, the IL-12/IL-18-driven IFN-? production and MAPK activation in Mekk3-deficient T cells was not affected suggesting that
MEKK3 may selectively
mediate the TCR induced
MAPK signals for IFN-? production