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EPHB2 — SGK1

Text-mined interactions from Literome

Lee et al., Eur J Neurosci 2006 (MAP Kinase Signaling System) : ERK was known to regulate sgk mRNA expression, but in the present study we have demonstrated that SGK is also a downstream target of the ERK signaling cascade ; ERK directly phosphorylates SGK at Ser78 and indirectly activates SGK at Thr256 and Ser422 through unknown intermediate molecules ... Furthermore, ERK activation of SGK is involved in spatial memory formation in rats
Won et al., J Hepatol 2009 (MAP Kinase Signaling System) : Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2 : implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration ... Infection of primary hepatocytes with an adenoviral vector encoding SGK1 enhanced the ERK phosphorylation under serum starved conditions and this was blocked by the expression of kinase-dead SGK1 ... Furthermore, SGK1 mediated the phosphorylation of ERK2 on Ser ( 29 ) in a serum dependent manner