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HGF — NFKB1

Text-mined interactions from Literome

Kim et al., J Surg Res 2000 : ( i ) Hypoosmolar WE medium phosphorylated p38, ERK 1 and 2, and SAPK/JNK by 5 min. ( ii ) Hypoosmolar WE medium activated NF-kappaB at 60 min. ( iii ) HGF phosphorylated all three MAPKs and activated NF-kappaB with profiles similar to those of hypoosmotic stress ... ( i ) Both hypoosmotic cell swelling and HGF phosphorylate p38, ERK 1 and 2, and SAPK/JNK, and ( ii ) HGF, but not hypoosmotic stress, activates NF-kappaB via p38 and ERK 1 and 2 phosphorylation
Müller et al., Mol Cell Biol 2002 : In this work we used the liver derived MLP29 cell line to study the possible involvement of NF-kappaB in HGF/Met signaling ... HGF stimulates NF-kappaB DNA binding and transcriptional activation via the canonical IkappaB phosphorylation-degradation cycle and via the extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase cascades
Yao et al., J Hepatol 2004 : We also observed activation of ERK1/2, p38 MAPK, Akt and NF-kappaB signaling pathways by HGF in WB-F344 cells
Ozawa et al., J Immunol 2004 (Periodontitis) : Furthermore, excess amounts of IL-2 restored the inhibitory effect of anti-IL-15, inhibition of NF-kappaB abrogated the expression of IL-2Rbeta and gammac, and IL-2-induced-nuclear translocation of NF-kappaB was completely inhibited by the RNA interference in HGF
Fan et al., Oncogene 2005 : Inhibitors of phosphatidylinositol-3'-kinase and Src family kinases significantly inhibited HGF/SF mediated activation of NF-kappaB , while inhibitors of MEK, protein kinase C, and p70 S6 kinase had a modest effect or no effect on NF-kappaB activity ... HGF/SF induced the expression of several known NF-kappaB target genes ( cIAP-1 ( cellular inhibitor of apoptosis-1 ), cIAP-2, and TRAF-2 ( TNF receptor associated factor-2 ) ) in an NF-kappaB dependent manner ; HGF/SF blocked the inhibition of expression of these genes by ADR
Zhou et al., Biochem Biophys Res Commun 2006 : HGF significantly promoted the expression of Bcl-2 and NF-kappaB , while decreasing the activities of caspase-3 and -9 without affecting Bax level
Wang et al., Chin J Cancer 2006 (Neoplasm Invasiveness...) : HGF promoted the expression of NF-kappaB protein in a time dependent manner
Maroni et al., Carcinogenesis 2007 (Breast Neoplasms...) : HGF induces CXCR4 and CXCL12 mediated tumor invasion through Ets1 and NF-kappaB
Gong et al., J Am Soc Nephrol 2006 (Chronic Disease...) : In addition, HGF suppressed NF-kappaB reporter gene activity that was induced by TNF-alpha and counteracted TNF-alpha elicited NF-kappaB interaction with kappaB elements at the E-selectin gene level
Fan et al., Oncogene 2007 : Ras effector pathways modulate scatter factor stimulated NF-kappaB signaling and protection against DNA damage
Wang et al., Cancer Lett 2007 (Neoplasm Invasiveness...) : CHM-1 also suppressed HGF induced Akt phosphorylation, and NF-kappaB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9
Matteucci et al., Mol Cancer Res 2007 (Breast Neoplasms...) : Thus, the CXCR4 induction by HGF in MCF-7 cells required NF-kappaB and Ets1 activations, downstream of phosphoinositide-3-kinase/Akt, whereas in HGF treated MDA-MB231 cells, HDAC3 activation via c-Src probably caused a reduction of transcription factor activities, such as that of NF-kappaB
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : Inhibition of MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
Gong et al., J Biol Chem 2008 (Inflammation...) : Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells ... Here we report that HGF through inactivation of GSK3beta suppresses NFkappaB p65 phosphorylation specifically at position Ser-468
Crisostomo et al., Am J Physiol Cell Physiol 2008 : VEGF, FGF2, and HGF expression was significantly reduced by NF kappa B inhibition ( 50 % decrease ) but not ERK or JNK inhibition
Syed et al., Toxicol Appl Pharmacol 2008 (Breast Neoplasms...) : Delphinidin was found to repress HGF activated NFkappaB transcription with a decrease in ( i ) phosphorylation of IKKalpha/beta and IkappaBalpha, and ( ii ) activation and nuclear translocation of NFkappaB/p65
Giannopoulou et al., Am J Pathol 2008 (Inflammation...) : However, HGF prevented p65 NF-kappaB binding to its cognate cis acting element in the RANTES promoter
Shen et al., DNA Cell Biol 1997 : In this report, we present evidence that shows HGF can stimulate the expression of AGP/EBP ( C/EBP beta ) and NF-kappaB , which are both key transcription factors responsible for the regulation of many genes under stress conditions or during the acute-phase response ... Activation of NF-kappaB by HGF was observed to precede the induction of agp/ebp