◀ Back to CCND1
CCND1 — HDAC1
Pathways - manually collected, often from reviews:
-
BioCarta cell cycle: g1/s check point:
RB/HDAC/ABL/E2F-1/DP-1 complex (E2F1-RB1-TFDP1-ABL1-HDAC1)
→
CYCLIN D1/CDK4/CDK6 complex (CCND1-CDK4-CDK6)
(modification, collaborate)
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1)
→
CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1)
(modification, collaborate)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of retinoblastoma protein:
CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A)
→
HDAC1 (HDAC1)
(modification, inhibits)
Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., Mol Cell Biol 2002
(Rhabdoid Tumor) :
In addition, INI1/hSNF5 repressed transcription of
cyclin D1 gene in MON, in a
histone deacetylase (HDAC) dependent manner
Rocha et al., Mol Cell Biol 2003
:
p53 represses
cyclin D1 transcription through down regulation of Bcl-3 and
inducing increased association of the p52 NF-kappaB subunit with
histone deacetylase 1
Yamaguchi et al., J Biol Chem 2005
:
HDAC inhibitors
suppressed the induction of both
cyclin D1 and collagenase-1 transcription by inhibiting the binding of c-Jun to the respective promoters
Findeisen et al., Arterioscler Thromb Vasc Biol 2011
(Disease Models, Animal...) :
Furthermore,
HDAC inhibition
repressed mitogen induced cyclin D1 mRNA expression and
cyclin D1 promoter activity