Gene interactions and pathways from curated databases and text-mining

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ABCA8 — APOA1

Text-mined interactions from Literome

Haidar et al., J Biol Chem 2004 (Tangier Disease) : Naturally occurring mutations of ABCA1 associated with Tangier disease ( C1477R, 2203X, and 2145X ) severely reduced apoA-I mediated cAMP production, ABCA1 phosphorylation, ( 125 ) I-apoA-I binding, and lipid efflux, without affecting forskolin mediated cAMP elevation
Fukuda et al., J Lipid Res 2008 : These results suggest the following new scenario of nascent HDL formation : ABCA1 , which colocalizes with apoA-I in acidic intracellular compartments, including the Golgi and endosome, increases acidity at the membrane surface on the luminal side by PS translocase activity and causes apoA-I to form nascent HDL