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CASP3 — MYC

Text-mined interactions from Literome

Vrana et al., Oncogene 1999 (Leukemia) : SAHA mediated apoptosis occurred within the G0G1 and S phase populations, and was associated with decreased mitochondrial membrane potential, caspase-3 activation , PARP degradation, hypophosphorylation/cleavage of pRB, and down-regulation of c-Myc , c-Myb, and B-Myb
Zhou et al., J Pharmacol Exp Ther 2000 : When p53, c-Myc, Bcl-2, Bcl-x ( L ), and Bax were measured by flow cytometry and the activities of caspase-1- and caspase-3-like protease determined with Ac-YVAD-AMC or Ac-DEVD-AMC as substrates, the profile of ROS induced changes in these apoptosis regulatory and effector proteins suggests that elevation of c-Myc , p53, and Bax and activation of caspase-3 play an important role in the apoptosis ... Bilobalide may block the apoptosis in the early stage and then attenuate the elevation of c-Myc , p53, and Bax and activation of caspase-3 in cells
You et al., J Cell Biol 2002 (Cell Transformation, Neoplastic) : Using an inducible c-MycER expression system, we found that Wnt/beta-catenin signaling suppressed apoptosis by inhibiting c-Myc induced release of cytochrome c and caspase activation
Jiang et al., Cell Biol Int 2003 : When c-Myc, Bcl-2 and Bax expression and caspase-3 activity were measured, using Ac-DEVD-AMC as a substrate, the changes in these apoptosis regulatory and effector proteins suggested that the elevation of c-Myc , decrease in Bcl-2 : Bax protein ratio, and caspase-3 activation all play a key role in apoptosis
Cavin et al., Mol Cancer Res 2005 (Carcinoma, Hepatocellular...) : Lastly, we show that NF-kappaB inhibits c-Myc induced activation of caspase-9 and caspase-3 through up-regulation of the antiapoptotic target genes Bcl-X ( L ) and X-linked inhibitor of apoptosis (XIAP)
Parreño et al., Mol Cancer Ther 2006 (Leukemia) : In conclusion, Bobel derivatives induce a caspase- and Bcl-2 independent cell death in which mitochondrial permeabilization and MYC down-regulation are involved
Baena et al., Exp Hematol 2007 : c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin ( - ) Sca-1 ( + ) c-Kit ( - ) cell generation through p21 ... c-Myc plays a role in HSC maintenance and differentiation and might be regulating generation of Lin ( - ) Sca-1 ( + ) c-Kit ( - ) through the cell-cycle regulator p21
Järvinen et al., Exp Cell Res 2011 : Here we found that in MycERT rat fibroblasts the activation of c-Myc led to an early activation and cleavage of the initiator caspase-8 , and concurrent processing and activation of the effector caspases 3 and 7 ... Further, we studied the potential involvement of the Fas- and tumor necrosis factor receptor (TNFR) mediated signaling in the activation of caspase-8 by c-Myc
Yang et al., Journal of carcinogenesis 2013 : This is followed by a precipitous loss of c-MYC protein, activation of caspase 3, and subsequent apoptotic cell death
Kagaya et al., Mol Cell Biol 1997 : Induction of s-Myc- and c-Myc mediated apoptotic cell death was effectively prevented by caspase inhibitors such as Z-Asp-CH2-DCB and Ac-DEVD-CHO