◀ Back to MAPK1
CHUK — MAPK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mizukami et al., Mol Cell Biol 2002
(MAP Kinase Signaling System) :
In the interleukin-1 signaling pathway, TAK1
MAPK kinase kinase ( MAPKKK ) mediates MAPK and
IKK activation via interaction with TRAF6, and TAB2 acts as an adapter linking TAK1 and TRAF6
de Alvaro et al., J Biol Chem 2004
(Insulin Resistance) :
Moreover, TNF-alpha produced
inhibitor kappaB kinase (IKK)-beta activation and inhibitor kappaB-beta and -alpha degradation in a p38
MAPK dependent manner, and treatment with salicylate ( an inhibitor of IKK ) completely restored insulin signaling
Zhang et al., Circ Res 2005
:
These 2 pathways are independent : inhibiting IKK does not block Ang II-induced phosphorylation of RSK, whereas inhibiting
mitogen activated protein kinase 1 does not
affect phosphorylation of
IKK
Lee et al., J Mol Med (Berl) 2009
:
These results suggest that p38
MAPK may
lead to the activation of
IKK and NF-kappaB signaling, resulting in enhanced DC maturation and CXCL2 expression in response to C. difficile toxin A stimulation
Chang et al., Pharmacol Res 2009
:
The YC-1 mediated increase in
IKKalpha/beta activation and kappaB-luciferase activity were
attenuated by GW 5074, a
MAPK/ERK kinase (MEK) inhibitor ( PD 98059 ), and an ERK2 inhibitor ( AG 126 )
Slomiany et al., Inflammopharmacology 2013
:
Induction in gastric mucosal prostaglandin and nitric oxide by Helicobacter pylori is dependent on
MAPK/ERK mediated activation of
IKK-ß and cPLA2 : modulatory effect of ghrelin
Lee et al., Proc Natl Acad Sci U S A 1998
:
We have previously shown that
mitogen activated protein kinase/ERK kinase kinase 1 ( MEKK1 ) can
induce both this site-specific phosphorylation of IkappaB alpha at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight
IkappaB kinase complex in vitro