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ABCB1 — PTGS2
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Miller et al., J Am Soc Nephrol 2006
:
It was shown previously that adenovirus mediated gene transfer of
COX-2 into rat GMC
led to increased expression and activity of
multidrug resistance protein 1 (MDR-1) , a membrane transporter that functions as an efflux pump for chemotherapeutic drugs, including Adriamycin ( ADR )
Roy et al., Cancer Chemother Pharmacol 2010
(Carcinoma, Hepatocellular...) :
The
role of
COX-2 in the regulation of the expression of
MDR1 , a P-glycoprotein involved in hepatocellular carcinoma cell line, HepG2, was studied in the present investigation
Nishanth et al., Eur J Pharmacol 2010
(Carcinoma, Hepatocellular...) :
The induction of
MDR1 expression by PGE2 and its down
regulation by C-PC and DPI ( Diphenylene iodonium, NADPH oxidase inhibitor ) or by
COX-2 knockdown suggest that the enhanced sensitivity of HepG2 cells to doxorubicin by C-PC is mediated by the down regulation of MDR1 expression ... The present study thus demonstrates the efficacy of C-PC in overcoming the
MDR1 mediated drug resistance in HepG2 cells by the down regulation of reactive oxygen species and
COX-2 pathways via the involvement of NF-?B and AP-1
Achari et al., Med Chem 2011
(Carcinoma, Hepatocellular...) :
The induction of MDR1 expression by PGE ( 2 ), a metabolite of COX-2, and its downregulation by COX-2 knockdown or CA implies that the enhanced sensitivity of HepG2 cells to doxorubicin by CA is mediated by the downregulation of
MDR1 expression, via
COX-2 dependent mechanism