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RNF19A — TP53
Text-mined interactions from Literome
Keller et al., Biochem Biophys Res Commun 1999
(Testicular Neoplasms) :
Thus, these results suggest that UV-stimulated
p53 phosphorylation at serine 389 is
mediated by the stress-responsive
p38MAPK
She et al., Cancer Res 2001
:
These data strongly suggest that both ERKs and
p38 kinase mediate resveratrol
induced activation of
p53 and apoptosis through phosphorylation of p53 at serine 15
Chouinard et al., Biochem J 2002
:
In HaCaT cells,
p53 was localized exclusively in the nucleus and its distribution and level were not
affected by UVB or
p38 inhibition
Shimada et al., Carcinogenesis 2003
(Prostatic Neoplasms) :
Inhibition of
p38 or NFkappaB
resulted in suppression of
p53 induction and apoptosis
Nuntharatanapong et al., Am J Physiol Heart Circ Physiol 2005
:
Moreover, inhibition of JNK with SP-600125 or dominant negative MKK7 inhibited only p21Cip1/Waf1 induction, whereas the
p38 MAPK inhibitor SB-203580 or dominant negative MKK4
inhibited both p21Cip1/Waf1 and
p53 induction
Ryer et al., J Biol Chem 2005
:
Protein kinase C delta induces apoptosis of vascular smooth muscle cells through
induction of the
tumor suppressor p53 by both
p38 dependent and p38 independent mechanisms
Kim et al., Arch Biochem Biophys 2005
(Carcinoma, Hepatocellular) :
Also, pharmacological inhibition of
p38 markedly
inhibited the phosphorylation, accumulated expression, and transactivation activity of
p53 in BaP treated cells
Saralidze et al., Georgian Med News 2005
(Radiation Injuries, Experimental) :
Increase of proapoptotic activity of
p-53 is
due to NO-stimulated DNA dependent protein kinase and
p-38 mitogen activated protein kinase
Nold et al., Thromb Haemost 2007
(Disease Models, Animal...) :
Furthermore, we showed that the regulation of the pro-apoptotic cell cycle regulator
p53 by PC and aPC is
dependent on the reduction of
p38MAPK activation
Lecona et al., Mol Cell Biol 2008
(Adenocarcinoma...) :
The interaction of
p53 with the promoter is
dependent on
p38 MAPK activity either in the absence or in the presence of butyrate
Karunakaran et al., J Neurosci 2008
(Disease Models, Animal...) :
Selective activation of
p38 mitogen activated protein kinase in dopaminergic neurons of substantia nigra
leads to nuclear translocation of
p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treated mice
Adam et al., Cancer Res 2009
(Neoplasms...) :
Furthermore,
induction of
p53 by
p38 was dependent on c-Jun down-regulation
Kim et al., Ann N Y Acad Sci 2009
(MAP Kinase Signaling System) :
Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the
activation of
p53 via JNK and
p38 mitogen activated protein kinase signaling
Shin et al., Int J Oncol 2010
(Breast Neoplasms) :
The results thus suggest that low doses of radiation suppress doxorubicin induced replicative senescence through the inhibition of
p38 dependent phosphorylation of
p53 and by activation of ERK1/2, without genomic damage
Ayli et al., Exp Dermatol 2010
:
Curcuminoids also promote the phosphorylation of
p53 on serine 15 in a dose dependent and
p38 dependent manner, suggesting that these compounds may activate p53
Lin et al., J Virol 2010
(HIV Infections) :
Furthermore, inhibition of
p38 mitogen activated protein kinase ( MAPK )
blocked phosphorylation of
p53 in the presence of Tat
Liu et al., Cardiovasc Res 2011
(MAP Kinase Signaling System...) :
Blocking
p53 led to augmented
p38ß activity and attenuated ROS, suggesting suppression of this antioxidant kinase by p53
Oeztuerk-Winder et al., EMBO J 2012
:
In addition, a signalling network involving the
p38a pathway, the
activation of
p53 and the regulation of the miR-17-92 cluster has been identified
Li et al., PloS one 2012
(Breast Neoplasms...) :
FANCF silencing increased JNK and
p38 mediated activation of
p53 in MX-treated breast cancer cells, activated the mitochondrial apoptosis pathway
Santoro et al., Carcinogenesis 2013
(Cell Transformation, Neoplastic) :
We have recently shown that melatonin induces
p38 dependent phosphorylation of both
p53 and histone H2AX
Wu et al., Radiology and oncology 2013
:
The inhibition of
p38 MAPK activation by SB203580 or siRNA reduced Eag protein level but
increased p53 protein level