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TGFB2 — TIMP3
Text-mined interactions from Literome
Neumann et al., Invest Ophthalmol Vis Sci 2008
:
TGF-beta2 increased the expression of elastin ( 5X [ rtPCR ] /6X [ WB ] ), ColVIalpha2 ( 3X/5X ), ColVIalpha3 ( 7X/9X ), MMP-2 ( 2X/2X ),
TIMP-1/-3 ( 1.5X/2X ), and PAI-1 ( 8X/4X ) compared to untreated controls
Qureshi et al., Biochim Biophys Acta 2008
:
Smad signaling pathway is a pivotal component of
tissue inhibitor of metalloproteinases-3 regulation by
transforming growth factor beta in human chondrocytes
Morris et al., Connect Tissue Res 2010
:
Stimulation with Interleukin-1ß and osteogenic protein-1 decreased while tumor necrosis factor alpha and
transforming growth factor beta increased
TIMP-3 protein levels ; however, TIMP-3 mRNA was not significantly affected by any of these treatments
Su et al., DNA Cell Biol 1996
(Osteoarthritis) :
Regulation of
tissue inhibitor of metalloproteinases-3 gene expression by
transforming growth factor-beta and dexamethasone in bovine and human articular chondrocytes
Mattila et al., J Invest Dermatol 1998
(Scleroderma, Localized) :
Specific activation of TIMP-3 gene expression in scleroderma skin fibroblasts in culture and in vivo suggests a role for TIMP-3 in the pathogenesis of dermal fibrosis via inhibition of turnover of fibrotic dermal extracellular matrix, possibly due to
upregulation of
TIMP-3 expression by
transforming growth factor-beta
Huang et al., J Clin Endocrinol Metab 1998
:
We have investigated the
roles of IL-1 beta and
transforming growth factor-beta ( TGF beta ) in regulating TIMP-1,
TIMP-3 , and 92-kDa type IV collagenase messenger ribonucleic acid ( mRNA ) expression in human endometrial stromal cells using quantitative competitive PCR
Fabunmi et al., Circ Res 1998
(Arteriosclerosis) :
Human smooth muscle cells constitutively expressed TIMP-1, -2 and -3 proteins ; platelet derived growth factor and
transforming growth factor-beta augmented levels of TIMP-1 and
TIMP-3 but not TIMP-2