◀ Back to SLC22A3
MMP28 — SLC22A3
Text-mined interactions from Literome
Illman et al., J Cell Sci 2006
(Lung Neoplasms...) :
Current results indicate that
epilysin can
induce EMT and cell invasion through a TGF-beta dependent mechanism suggesting novel biological roles for this enzyme in the regulation of epithelial cell function and in the induction of carcinogenesis
Stallings-Mann et al., Cells Tissues Organs 2007
(Cell Transformation, Neoplastic) :
We have identified the induction of Rac1b, an alternatively spliced variant of Rac1, as a key event in
MMP induced
EMT
Lee et al., Carcinogenesis 2008
(Breast Neoplasms...) :
Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances
EMT induced by TGF-beta in mammary epithelial cells via a
MMP dependent mechanism
Illman et al., Exp Dermatol 2008
:
Current results suggest a plausible interaction between epilysin and TGF-beta also under physiological circumstances, where
epilysin activity may not
induce EMT but, instead, trigger less permanent changes in TGF-beta signalling and cell motility
Tan et al., Am J Pathol 2010
(Fibrosis...) :
AMCM induced tubular cell
EMT in C1.1 cells was
inhibited by broad-spectrum
MMP inhibitor ( GM6001 ), MMP-2/9 inhibitor, and in AMCM after MMP-9 removal by monoclonal Ab against MMP-9 ... Furthermore,
MMP-9 induced tubular cell
EMT in C1.1 cells to an extent similar to transforming growth factor-beta