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RAB5A — VPS39

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM Class C VPS/HOPS complex: Class C VPS/HOPS complex complex (EEA1-RAB5A-VPS11-VPS16-VPS18-VPS39) Rink et al., Cell 2005
• IRef Corum Interaction: Complex of RAB5A-EEA1-VPS16-VPS39-VPS11-VPS18 (association, affinity chromatography technology) Rink et al., Cell 2005

Text-mined interactions from Literome

Hama et al., J Biol Chem 1999 : We tested the ability of Vps9p to stimulate the intrinsic guanine nucleotide exchange activity of Rab5 , which is a mammalian sequence homologue of Vps21p, and Ypt7p, which is another yeast Rab protein involved in vacuolar protein transport
Ravikumar et al., J Cell Sci 2008 (Disease Models, Animal...) : We tried to identify a mechanism for the Rab5 effects in our HD model systems, and our data suggest that Rab5 acts at an early stage of autophagosome formation in a macromolecular complex that contains beclin 1 (BECN1) and Vps34. Interestingly chemical or genetic inhibition of endocytosis also impeded macroautophagy, and enhanced aggregation and toxicity of mutant huntingtin