Yang et al., Nat Immunol 2011
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Whereas STAT3 induced IL-17 and the transcription factor ROR?t and inhibited the transcription factor Foxp3 , IL-2 inhibited IL-17 independently of Foxp3 and ROR?t
Wang et al., PloS one 2011
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Assay with transwell systems showed that cell-cell contact was necessary for IL-6 production to a threshold to activate Th17 transcriptional factor ROR?t and to inhibit Treg counterpart Foxp3 Yoshida et al., Biochem Biophys Res Commun 2013
(Encephalomyelitis, Autoimmune, Experimental) :
Among them, we found that Kenpaullone, a GSK3-ß and CDK inhibitor, efficiently suppressed TGF-ß mediated ROR?t induction and enhanced Foxp3 induction in primary T cells