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FRS2 — SRC

Pathways - manually collected, often from reviews:

• NCI Pathway Database FGF signaling pathway: Src (SRC) → FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2) (modification, activates)
  Li et al., J Cell Sci 2004, Lao et al., J Biol Chem 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database FGF signaling pathway: Src (SRC) → FGFR/FGF/Syndecan-2/FRS2/Sprouty2 complex (SDC2-FRS2-SPRY2) (modification, activates)
  Li et al., J Cell Sci 2004, Lao et al., J Biol Chem 2006
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SRC — FRS2 (in vitro) Meakin et al., J Biol Chem 1999

Text-mined interactions from Literome

Li et al., J Cell Sci 2004 : FRS2 dependent SRC activation is required for fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of ERK activity ... Activation of SRC via fibroblast growth factor signalling is dependent upon FRS2 and fibroblast growth factor receptor kinase activity
Li et al., J Dermatol Sci 2009 : Intracellularly, c-Src was phosphorylated by wounding but its inhibitor, PP1, significantly inhibited KGFR activation and associated FRS2 phosphorylation