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SLC22A3 — TP53

Text-mined interactions from Literome

Boominathan et al., PloS one 2010 : Together, this study provides mechanistic insights into how p53 , p63, and p73 regulate the components of the miRNA processing ; and how p53, TA-p63, and TA-p73 regulated miRNAs inhibit tumorigenesis, EMT , metastasis, and cancer stem cell proliferation
Kim et al., J Exp Med 2011 (Carcinoma, Hepatocellular...) : Our findings indicate that p53 can regulate EMT , and that p53 regulated miRNAs are critical mediators of p53 regulated EMT
Dong et al., Oncogene 2013 (Disease Progression...) : The tumor suppressor gene p53 has been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis by regulating microRNA ( miRNA ) expression ... Ectopic expression of p53 mutants repressed the expression of miR-130b and triggered ZEB1 dependent EMT and cancer cell invasion ... Furthermore, re-expression of miR-130b suppressed mutant p53 induced EMT and ZEB1 expression
Termén et al., J Cell Physiol 2013 : Here, we analyzed the role of the tumor suppressor protein p53 in TGFß induced EMT in a well established mammary epithelial cell model ... Global reduction of both forms of p53 led to an enhanced EMT response to TGFß ... After silencing both p53 forms, rescue experiments using either wild type or R277C mutant p53 revealed that wild type p53 inhibited, whereas the R277C mutant did not significantly affect , the TGFß-driven EMT response
Ren et al., Int J Oncol 2013 (Prostatic Neoplasms) : Importantly, WT-p53 upregulated the expression of miR-145, and the inhibitory effects of WT-p53 on migration, invasion, EMT and stemness of PC-3 cells were reversed by anti-miR-145