◀ Back to IFNG
GBP1 — IFNG
Text-mined interactions from Literome
Saunders et al., J Invest Dermatol 1999
(Carcinoma, Squamous Cell...) :
In order to understand the proximate events regulating interferon-gamma action we studied the relationship between
interferon-gamma mediated induction of a cytoplasmic
guanylate binding protein and the expression of growth and differentiation marker genes in normal and transformed keratinocytes
Prakash et al., EMBO J 2000
:
The
interferon-gamma induced
guanylate binding protein 1 (GBP1) belongs to a special class of large GTP- binding proteins of 60-100 kDa with unique characteristics
Kumar et al., J Clin Endocrinol Metab 2001
:
IFN-gamma was, however, a more potent
inducer of
GBP1 than IFN-alpha
Doan et al., Oncogene 2004
:
Lack of INI1 also did not prevent
interferon gamma (IFNgamma) mediated induction of CIITA, which is BRG1 dependent, and
GBP-1 , which is BRG1 enhanced, and reintroduction of INI1 had minimal effects
Kunzelmann et al., Methods Enzymol 2005
:
The synthesis of human
guanylate binding protein 1 ( hGBP1 ) is
induced by
interferon-gamma and its biological function is related to antiviral activity and regulation of proliferation
Tripal et al., J Interferon Cytokine Res 2007
:
IFN-gamma , tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta)
induced the expression of
HuGBP-1 , HuGBP-2, and HuGBP-3 at similar high levels
Hulst et al., Arch Virol 2008
(Rotavirus Infections...) :
Furthermore, up-regulation was observed for
IFN-gamma induced
guanylate binding protein 2, a protein that effectively inhibited VSV and EMCV replication in vitro ( Arch Virol 150 : 1213-1220, 2005 )
Abdullah et al., J Mol Biol 2009
:
Unlike other GTPases,
interferon-gamma induced human
guanylate binding protein-1 has the ability to hydrolyze GTP to both GDP and GMP, with GMP being the major product of the reaction
Lipnik et al., Mol Med 2010
(Adenocarcinoma...) :
Interferon gamma induced human
guanylate binding protein 1 inhibits mammary tumor growth in mice
Messmer-Blust et al., Mol Biol Cell 2010
(Melanoma) :
The
interferon-gamma induced murine
guanylate binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet derived growth factor treatment : role for phosphatidylinositol 3-kinase ... Expression of the
IFN-gamma induced GTPase murine
guanylate binding protein-2 ( mGBP-2 ) can phenocopy this inhibition and small interfering RNA knockdown of mGBP-2 prevents IFN-gamma mediated inhibition of cell spreading
Nicolet et al., J Immunol 1994
:
We have investigated the regulation of an activation associated
guanylate binding protein gene ( mGBP-1/mag-1 ) in murine macrophage cell lines in
response to the cytokine
IFN-gamma