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IFNG — RPE
Text-mined interactions from Literome
Sugita et al., Invest Ophthalmol Vis Sci 2009
(Autoimmune Diseases...) :
PD-L1 ( + )
RPE in the
presence of
IFNgamma selectively suppressed PD-1 ( + ) T-cell activation
Mesri et al., Immunology 1994
:
To identify the signals involved in the adhesion and subsequent migration of lymphocytes across the endothelium ( REC ) and pigment epithelium ( RPE ) of the blood-retina barrier we have studied the effects of monoclonal antibodies ( mAb ) to rat adhesion/accessory molecules on the binding of normal and concanavalin A ( Con A ) -activated rat spleen lymphocytes to cultured unstimulated and
interferon-gamma (IFN-gamma) stimulated
RPE and REC ... However,
IFN-gamma stimulated
RPE and REC did not demonstrate a significant increase in adhesiveness for normal lymphocytes highlighting the importance of lymphocyte integrin activation from low-affinity to high-affinity state
Gabrielian et al., Invest Ophthalmol Vis Sci 1994
:
Staurosporine pretreatment suppressed HLA-DR expression by
IFN-gamma stimulated
RPE cells, but this was not additive with TGF-beta
Elner et al., Exp Eye Res 1997
:
Dose- and time dependent
RPE cell MCP-1 secretion was also
observed following IL-1 beta > TNF-alpha >
IFN-gamma stimulation, with an average of 4 % of the total MCP-1 retained within RPE