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EGF — PTGS1

Text-mined interactions from Literome

Yucel-Lindberg et al., Biochem Biophys Res Commun 1999 : Neither IL-1beta EGF nor the combination of IL-1beta and EGF enhanced COX-1 mRNA levels in gingival fibroblasts
Jin et al., Prostaglandins Other Lipid Mediat 2007 : Though EGF promoted the expression of both COX-1 and COX-2, the rescue experiment indicated that combined treatment of PGE ( 1 ) showed better rescuing effect on NS398 inhibition than SC560 at 10 ( -6 ) M, which implies COX-2 plays the predominant role in mediating EGF action
Hamasaki et al., Prostaglandins Leukot Essent Fatty Acids 1995 : EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways ... These results indicate that EGF stimulates de novo synthesis of PGHS-1 and PGHS-2 mRNA through a signal transduction pathway which is independent from PKC associated mechanisms but dependent upon the tyrosine kinase activity of the EGF receptor
Kaplan et al., J Biol Chem 1997 : Moreover, basic fibroblast growth factor, but not epidermal growth factor , caused similar increases in COX-1 , which is consistent with expression characteristics of other delayed response genes in PC12 cells
Bany et al., Dev Genet 1997 : The present study examined the effect of epidermal growth factor on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in these cells ... Finally, the effects of epidermal growth factor and dexamethasone on steady-state cyclooxygenase-1 and cyclooxygenase-2 mRNA levels paralleled the changes in the levels of immunocytochemical staining for these enzymes in the cells ... The results of this study suggest that epidermal growth factor causes an increase in cyclooxygenase-1 and cyclooxygenase-2 gene expression in endometrial stromal cells isolated from the uteri of rats which have been sensitized for decidualization, and that the previously reported transcriptional- and translational dependent increases in cyclooxygenase activity in these cells in response to epidermal growth factor were likely due to its effect on cyclooxygenase-1