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ABL1 — SOS1

Pathways - manually collected, often from reviews:

• NCI Pathway Database PDGFR-beta signaling pathway: Eps8/ABI1/SOS1 complex (EPS8-ABI1-SOS1) → c-Abl (ABL1) (modification, collaborate) Sini et al., Nat Cell Biol 2004
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOS1 — ABL1 (physical association, affinity chromatography technology) Puil et al., EMBO J 1994*

Text-mined interactions from Literome

Sini et al., Nat Cell Biol 2004 : Abl dependent tyrosine phosphorylation of Sos-1 mediates growth-factor induced Rac activation ... Sos-1 and Abl interact in vivo, and Abl induced tyrosine phosphorylation of Sos-1 is sufficient to elicit its Rac-GEF activity in vitro
Modi et al., Leukemia 2011 (Cell Transformation, Neoplastic...) : The adapter protein growth factor receptor binding protein-2 ( Grb2 ) can bind phosphorylated BCR/ABL-Y177 , induce Grb2-SoS complex formation and activate Ras signaling