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CSE — IL8

Text-mined interactions from Literome

Kashyap et al., J Investig Med 2002 : Cigarette smoke extract (CSE) activates protein kinase C ( PKC ) and augments complement factor 5a ( C5a ) -stimulated release of the proinflammatory cytokine IL-8 in human bronchial epithelial cells ( HBEC ) ... Collectively, these data suggest that PKC activators in addition to CSE augment C5a stimulated IL-8 release from HBEC and that CSE and C5a stimulate IL-8 release in HBEC by activating the calcium dependent PKCalpha isoform
Oltmanns et al., Respir Res 2005 : CSE ( 5, 10 and 15 % ) induced IL-8 release and expression without effect on eotaxin or RANTES release ... TNFalpha enhanced CSE induced IL-8 release and expression ... The effects of CSE on IL-8 release were inhibited by glutathione ( GSH ) and associated with the induction of the oxidant sensing protein, heme oxygenase-1
Kode et al., Respir Res 2006 : CSE , however, induced IL-8 and IL-6 release in primary cell lines in a dose dependent manner, which was associated with the nuclear translocation of NF-kappaB in SAEC
Li et al., Am J Physiol Lung Cell Mol Physiol 2007 : We applied cigarette smoke water extract (CSE) to primary human lung fibroblasts and found that CSE significantly increased CXC chemokine IL-8 production
Kent et al., Cytokine 2008 (Pulmonary Disease, Chronic Obstructive) : IL-8 mRNA levels were up-regulated by 10 % CSE ( 2.25-fold increase, 95 % CI 1.28-4.00 )
Mahanonda et al., J Periodontal Res 2009 : The effect of CSE or nicotine on the expression of the antimicrobial peptide human beta-defensin-2 (hBD-2) and the pro-inflammatory cytokine interleukin (IL)-8 in stimulated HGEC cultures was evaluated by RT-PCR and enzyme linked immunosorbent assay
Mortaz et al., Respir Res 2009 : We observed that CSE augmented the production of IL-8 and suppressed the release of TNF-alpha, IL-6 and IFN-alpha
Mulligan et al., American journal of rhinology & allergy 2009 : CSE induces both secretion and intracellular production of the proinflammatory cytokine IL-8 by HSNE cells in a dose dependent manner ... CSE induces secretion of IL-8 in NHBEs that is also suppressed by SOD
Wang et al., American journal of rhinology & allergy 2009 (Inflammation...) : CSE increased RV-induced TLR3 expression and RV-induced IL-8 secretion at lower concentrations in A549 cells
Kent et al., Int Immunopharmacol 2010 (Pulmonary Disease, Chronic Obstructive) : qPCR and ELISA showed that IL-8 levels were increased by CSE , with suppression by dexamethasone
Milara et al., Eur J Pharm Sci 2010 : CSE ( 2.5-10 % ) induced upregulation of IL-6, IL-8 and Ang-2, and decreased Ang-1 expression in parallel to apoptosis which were partially suppressed by sildenafil, 8-Br-cGMP, DPI and NAC
Simone et al., PloS one 2011 : CSE enhanced IL-8 production in a time- and a dose dependent manner ... Lycopene pre-treatment resulted in a significant inhibition of CSE induced IL-8 expression at both mRNA and protein levels ... NF-kB controlled the transcription of IL-8 induced by CSE , since PDTC prevented such a production ... Taken together, our data indicate that lycopene prevented CSE induced IL-8 production through a mechanism involving an inactivation of NF-kB
Heijink et al., Respir Res 2011 (Pulmonary Disease, Chronic Obstructive) : We studied the effects of cigarette smoke extract (CSE) and metalloproteinase inhibitors on TGF-a and IL-8 release in primary bronchial epithelial cells ( PBECs ) from COPD patients, healthy smokers and non-smokers ... CSE did not induce ADAM17 dependent TGF-a shedding, while it slightly augmented the production of IL-8
Aldhous et al., PloS one 2011 : CSE also reduced NOD2 expression, CCL20 and IL8 production seen with MDP-stimulation of SW480 cells pre treated with combinations of TNFa and CSE
Oldenburger et al., PloS one 2012 (Pulmonary Disease, Chronic Obstructive) : We report here that next to the ß ( 2 ) -agonist fenoterol, direct and specific activation of either exchange protein directly activated by cAMP ( Epac ) or protein kinase A (PKA) reduced cigarette smoke extract (CSE) induced IL-8 mRNA expression and protein release by human ASM cells
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System) : Stimulation of these cells with CS extract (CSE) increased IL-8 release and ERK-1/2 phosphorylation, as well as I?-Ba degradation and p65 NF-?B subunit phosphorylation ... In addition, inhibitors of TAK1 and the NF-?B ( SC-514 ; 50 µM ) and ERK-1/2 ( U-0126 ; 3 µM ) signaling inhibited the CSE induced IL-8 release by ASM cells
Li et al., J Immunol 2012 (Acute Disease...) : In vitro biochemical data correlate CSE mediated IL-8 release with Shp2 regulated epidermal growth factor receptor/Grb-2 associated binders/MAPK signaling
Moretto et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System...) : We examined the acute effect of aqueous cigarette smoke extract (CSE) on IL-8 expression in primary human pulmonary cells, in particular in normal human bronchial smooth muscle cells ( HBSMCs )
Heijink et al., Thorax 2013 (Pulmonary Disease, Chronic Obstructive) : Moreover, WNT-4 potentiated the CSE induced upregulation of IL-8 and VEGF
Moon et al., PloS one 2013 : CS and cigarette smoke extracts (CSE) both induce IL-8 secretion and subsequently, IL-8 recruits inflammatory cells into the lung parenchyma ... However, the molecular and cellular mechanisms by which CSE triggers IL-8 release remain not completely understood ... In this study, we identified a novel extracellular matrix ( ECM ) molecule, CCN1, which mediated CSE induced IL-8 secretion by lung epithelial cells
Mio et al., Am J Respir Crit Care Med 1997 : To evaluate this, the effect of cigarette smoke extract (CSE) on IL-8 release from cultured human bronchial epithelial cells was examined ... CSE augmented IL-8 release from bronchial epithelial cells in a concentration- and time dependent manner ... Four cell strains were tested and showed increased IL-8 release in response to CSE