Gene interactions and pathways from curated databases and text-mining

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HRAS — IGF1

Pathways - manually collected, often from reviews:

  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GTP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)
  • NCI Pathway Database IGF1 pathway: IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1) → HRAS/GDP complex (HRAS) (modification, activates)

Text-mined interactions from Literome

Burgering et al., Mol Cell Biol 1989 (Cell Transformation, Neoplastic) : This implies that overexpression of normal H-ras in the presence of insulin/IGF-1 is functionally similar to the expression of mutant H-ras, since mutant H-ras can circumvent this block by itself
Valverde et al., Exp Cell Res 1995 : Moreover, DBcAMP inhibited in parallel H-ras mRNA expression, p21 ras , and proliferating cellular nuclear antigen protein content induced by IGF-I at 24 and 48 h of culture, respectively, suggesting the involvement of p21 ras in the progression of fetal brown adipocytes through the S phase of the cell cycle and DNA synthesis
Luttrell et al., J Biol Chem 1995 : The IGF1 , LPA, and EGF receptor mediated signals are all sensitive to inhibitors of tyrosine protein kinases, require p21ras activation, and are independent of protein kinase C
Dawson et al., Cancer Res 1995 : Expression of mutant p21ras induces insulin-like growth factor 1 secretion in thyroid epithelial cells ... Expression of mutant p21ras in these cells, induced by Zn2+, resulted in an approximate 30-fold increase in the IGF-1 production rate, reaching a level exceeding that of human embryo fibroblasts
Robinson et al., Endocrinology 1994 : The aims of this study were to determine if insulin and IGF-I activate p21ras in fetal chick forebrain neurons and if activation of p21ras mediates the neurotrophic actions of these peptides ... Insulin and IGF-I increased the ratio of GTP/GTP + GDP by 31 +/- 9.0 % and 36 +/- 8.0 %, respectively, p21Ras activation by insulin and IGF-I was maximal within 5 min ... Pretreatment of neurons with lovastatin ( 2 micrograms/ml ), an inhibitor of ras isoprenylation, completely blocked the activation of p21ras by insulin and IGF-I ... We conclude that insulin and IGF-I activate p21ras in fetal chick forebrain neurons by increasing the amount of GTP bound to p21ras ... The activation of neuronal p21ras is necessary for insulin and IGF-I to promote survival and differentiation in these neurons
Jhun et al., J Biol Chem 1994 : Insulin and insulin-like growth factor-I signal transduction requires p21ras ... We have investigated the role of cellular p21ras protein in insulin and insulin-like growth factor-I (IGF-I) signaling pathways
Lorenzo et al., J Cell Biol 1993 : IGF-I increased mRNA expression of the early-response genes c-fos ( 30 min ), c-myc ( 2 and 24 h ), and H-ras ( 4 and 24 h ) ... IGF-I or 10 % FCS, however, similarly increased the mRNA late expression of c-myc, H-ras , c-raf, beta-actin, and glucose 6-phosphate dehydrogenase (G6PD) at 72 h, as compared to quiescent cells