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LTA — PTGS2

Text-mined interactions from Literome

Lee et al., Am J Pathol 2010 (Inflammation) : In this study, LTA induced cPLA(2) and COX-2 expression and PGE ( 2 ) or IL-6 synthesis were attenuated by transfection with siRNAs of TLR2, MyD88, Akt, p42, p38, JNK2, and p65 or pretreatment with the inhibitors of PI3K ( LY294002 ), p38 ( SB202190 ), MEK1/2 ( U0126 ), JNK1/2 ( SP600125 ), and NF-kappaB ( helenalin ) in human tracheal smooth muscle cells ( HTSMCs ) ... LTA also induced cPLA(2) and COX-2 expression and leukocyte count in bronchoalveolar lavage fluid in mice
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : Administration of TLR2 antagonist effectively inhibited LTA induced NO, iNOS, and COX-2 expression ... We also found that LTA induced iNOS and COX-2 up-regulation were attenuated by p38, JNK, and PI3-kinase inhibitors ... Treatment of cells with NF-?B and AP-1 inhibitors antagonized LTA induced iNOS and COX-2 expression