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DUSP1 — IRF6
Text-mined interactions from Literome
Chen et al., J Immunol 2002
:
Induction of
MKP-1 by
LPS was found to be extracellular signal regulated kinase dependent and involved enhanced gene expression and increased protein stability
Stawowy et al., Biochem Biophys Res Commun 2003
:
Induction of MKP-1 by LPS was inhibited by the protein kinase C ( PKC ) -inhibitor calphostin C, but not by the ERK1/2-pathway inhibitor PD98059, suggesting that PKC but not ERK1/2 is required for
LPS mediated
MKP-1 induction in CFBs
Zhao et al., J Biol Chem 2005
(Inflammation...) :
MKP-1 was rapidly
induced by
LPS , and its induction correlated with the dephosphorylation of these MAP kinases
Sánchez-Tilló et al., J Biol Chem 2007
(MAP Kinase Signaling System) :
However, only the JNK1 isoform was phosphorylated and, as determined in single knock-out mice, was necessary for
Mkp1 induction by M-CSF or
LPS ... Our results demonstrate a critical role for JNK1 in the regulation of
Mkp1 induction and in
LPS dependent macrophage
activation
Ichikawa et al., Endocrinology 2008
(Inflammation) :
In contrast, LNO ( 2 ) or OA-NO ( 2 ) alone up-regulated both mRNA and protein levels of MAPK phosphatase 1 (MKP-1) and strongly augmented the
LPS induced
MKP-1 protein expression
Bhavsar et al., Thorax 2008
(Asthma) :
MKP-1 expression
induced by dexamethasone and
LPS , expressed as a ratio of LPS induced expression, was reduced in severe asthma
Cho et al., Inflamm Res 2009
:
In view of the potential roles of PKA and MSK for MKP-1 induction and the ability of H89 to inhibit these kinases, this study examined the effect of H89 on
MKP-1 induction by
LPS and the role of cyclic-AMP response element binding protein ( CREB ) in the MKP-1 induction
Casals-Casas et al., Eur J Immunol 2009
:
CREB and AP-1 activation regulates
MKP-1 induction by
LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation
Wang et al., J Biol Chem 2009
:
Both accelerated gene transcription and enhanced mRNA stability contribute to the increases in iNOS expression in
LPS stimulated
MKP-1 ( -/- ) macrophages
Turpeinen et al., Mediators Inflamm 2011
:
Stimulation with cytokine mixture or
LPS enhanced also
DUSP1 expression
Zhang et al., Cardiovasc Res 2012
(Endotoxemia...) :
Lipopolysaccharide (LPS) increased
MKP1 expression in the myocardium in vivo and in cultured neonatal cardiomyocytes in vitro ... Inhibition of Rac1 and PAK1 by a dominant negative Rac1 adenovirus ( Ad-Rac1N17 ) and PAK1 siRNA, respectively, blocked
LPS induced
MKP1 expression in cardiomyocytes
Lee et al., J Cell Biochem 2013
:
NaHS blocked nicotine and
LPS induced activation of p38, ERK,
MKP-1 , PI3K, PKC, and PKC isoenzymes, and NF-?B