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HGF — TNF
Text-mined interactions from Literome
Kobayashi et al., J Dent Res 1999
:
rhIL-1 beta and rh
tumor necrosis factor (TNF)-alpha stimulated
HGF to produce intracellular IL-1 alpha, whereas rh interleukin-6 (IL-6), rh interleukin-4 (IL-4), and rh interferon (IFN)-gamma did not do so
Jeschke et al., Shock 1999
(Acute-Phase Reaction...) :
RhGH/HGF increased serum
TNF-alpha on day 2 after burn, while it decreased serum IL-1beta on day 1 after burn compared with placebo ( P < 0.05 )
Noguchi et al., J Periodontal Res 1999
:
Both the agents downregulated ICAM-1 expression in
TNF alpha stimulated
HGF
Jeschke et al., Crit Care Med 2000
(Acute-Phase Reaction...) :
HGF increased the hepatic gene expression of
tumor necrosis factor-alpha compared with controls ( p < .05 )
Ohe et al., J Interferon Cytokine Res 2000
:
As
human gingival fibroblasts (HGF) can be potential
targets for
TNF-alpha in inflamed gingiva, we hypothesized that HGF partially modulate the cellular responses to TNF-alpha by regulating their own TNFR
Noguchi et al., J Periodontal Res 2001
(Periodontal Diseases) :
From these data, we suggest that PGF2alpha upregulates IL-6 production through FP receptors in HGF, that PGF2alpha synergistically enhances IL-6 production in IL-1beta- and
TNFalpha stimulated
HGF , and that PGF2alpha induced IL-6 production may be dependent on intracellular Ca2+ mobilization and be downregulated by PKC activation
Kuroiwa et al., J Clin Invest 2001
(Disease Models, Animal...) :
HGF also markedly
suppressed IFN-gamma and
TNF-alpha expression in the intestine and liver and decreased the serum IL-12
McCourt et al., Eur J Surg Oncol 2001
(Neovascularization, Pathologic) :
TNF-alpha , LPS and fMLP stimulation
resulted in significantly increased release of PMN
HGF ( 755+/-216, 484+/-221 and 565+/-278 pg/ml, respectively ) compared to controls ( 118+/-42 pg/ml )
Nakao et al., Mol Cell Biochem 2002
:
Gel mobility shift assays with a radiolabelled COX-2-NFkappaB oligonucleotide ( nts -223 to -214 ) revealed an increase in the binding of nuclear proteins from
TNF-alpha stimulated
HGF
Armbrust et al., Liver 2002
(Drug-Induced Liver Injury) :
Hepatocyte growth factor in MNP is not directly
induced by interferon-alpha, interferon-gamma or
tumour necrosis factor-alpha (TNF-alpha)
Matsumoto et al., Biochem Biophys Res Commun 1992
:
Tumor necrosis factor-alpha and interferon-gamma but no other cytokine tested
had slightly stimulatory effects on
HGF production
Dong et al., Zhonghua Nei Ke Za Zhi 1992
(Hepatitis B...) :
TNF activity was increased in rats with experimental liver failure ;
HGF and PGE1 can protect experimental liver necrosis and
reduce the serum
TNF activity
Takami et al., Biochem Biophys Res Commun 2004
:
HGF production is
induced by the activation of protein kinase A and protein kinase C-mediated pathways, interleukin (IL)-1,
tumor necrosis factor (TNF)-alpha , and epidermal growth factor (EGF) in mesenchymal cells ... We here report that IL-1 and
TNF-alpha , hitherto regarded as HGF inducers, potently
inhibited HGF production stimulated by other HGF inducers ... IL-1alpha, IL-1beta, and
TNF-alpha alone had minimal stimulating effects on HGF production in human dermal fibroblasts, but they strongly
inhibited production of
HGF induced by cholera toxin, 8-bromo-cAMP, EGF, and phorbol 12-myristate 13-acetate ( PMA )
Takami et al., Biochem Biophys Res Commun 2005
(Inflammation) :
Candidates of the factors are inflammatory cytokines released by polymorphonuclear and mononuclear cells infiltrating the wounded area, but
HGF production in human dermal fibroblasts is only slightly
induced by interleukin (IL)-1,
tumor necrosis factor (TNF)-alpha or interferon (IFN)-gamma
Gong et al., Biochem Biophys Res Commun 2005
:
In contrast, expression of S9A-GSK3beta abolished
HGF inhibition of basal and
TNF-alpha stimulated RANTES expression
Wang et al., Am J Physiol Regul Integr Comp Physiol 2006
:
Human progenitor cells from bone marrow or adipose tissue produce VEGF,
HGF , and IGF-I in
response to
TNF by a p38 MAPK dependent mechanism ... We hypothesized that
tumor necrosis factor-alpha (TNF-alpha) stimulated progenitor cell secretion of vascular endothelial growth factor ( VEGF ),
hepatocyte growth factor (HGF) , and insulin-like growth factor I (IGF-I) by a p38 mitogen activated protein kinase ( MAPK ) -dependent mechanism ... Secretion of VEGF,
HGF , and IGF-I in hMSCs and hAPCs was significantly increased by
stimulation with
TNF and was associated with increased activation of p38 MAPK ... The p38 MAPK inhibitor decreased production of
TNF stimulated VEGF,
HGF , and IGF-I in hMSCs and hAPCs
Bell et al., Am J Physiol Endocrinol Metab 2006
(Obesity...) :
TNF-alpha ( 24 h treatment ) significantly
increased HGF release from subcutaneous adipocytes 23.6 +/- 8.3 % over control ( P = 0.02 )
Crisostomo et al., Am J Physiol Cell Physiol 2008
:
TNF-alpha , LPS, and hypoxia significantly
increased human MSC VEGF, FGF2,
HGF , and IGF-1 production versus controls
Yu et al., Zhong Xi Yi Jie He Xue Bao 2009
:
The expressions of oncogenes ( ERBB2, ETS2, FOS ), apoptosis gene ( BCL2L1 ), cyclin dependent kinases ( CDK4, CDC25A ), and growth factor and receptors (
HGF , FGFR2, TGFBR ) were significantly
enhanced , while the expressions of the anti-oncogenes ( KAI1, SERPINB5 ), apoptosis genes ( BAD and
TNF ) and cyclin dependent kinase inhibiting factor ( CDKN2A ) were obviously reduced in ectopic tissue as compared with those in eutopic tissue from patients with endometriosis
Hosokawa et al., Clin Exp Immunol 2009
:
Interleukin (IL)-4, IL-13 and CpG DNA up-regulated CXCR6 expression by
TNF-alpha stimulated
HGF
Wang et al., Am J Physiol Cell Physiol 2009
:
We conclude that 1 ) novel cross talk occurs between tumor necrosis factor receptor and TGF-alpha/epidermal growth factor receptor in stimulating MSC HGF production ; 2 ) this cross talk is mediated, at least partially, via activation of MEK, p38, and PI-3K ; 3 ) TGF-alpha stimulates MSCs to produce HGF by MEK, p38, PI-3K, and TNFR2 dependent mechanisms ; and 4 ) TNFR1 acts to decrease basal TGF-alpha and
TNF-alpha stimulated
HGF
Takahashi et al., Indian J Dermatol 2009
:
Furthermore,
TNF-alpha induced secretion of IL-6, IL-8, EGF,
HGF , TGF-alpha, epiregulin, and amphiregulin were compared among these keratinocytes ... The significant induction of
TNF-alpha increased IL-6, IL-8, EGF,
HGF , TGF-alpha, epiregulin, and amphiregulin, but the increase in these cytokines and growth factors were not different among normal skin, uninvolved, and involved psoriasis
Shintani et al., Atherosclerosis 2011
(Aortic Aneurysm, Abdominal) :
In ex vivo cultures of human AAA tissue, exogenously added
HGF in the
presence of
tumor necrosis factor-alpha ( TNF-a ) enhanced the secretion of anti-inflammatory cytokine interleukin-10 (IL-10) and suppressed the secretion of proinflammatory monocyte/macrophage chemotactic protein-1 (MCP-1)
Wang et al., Hum Gene Ther 2013
(Disease Models, Animal...) :
MSCs-HGF could
reduce secretion and expression of proinflammatory cytokines, including
tumor necrosis factor-a , interferon-?, interleukin (IL)-6, and intercellular adhesion molecule-1, and increase the expression of antiinflammatory cytokine IL-10
Tamura et al., J Biol Chem 1993
:
Enhancement of human
hepatocyte growth factor production by interleukin-1 alpha and -1 beta and
tumor necrosis factor-alpha by fibroblasts in culture
Takigawa et al., J Periodontol 1994
(Gingivitis) :
The combination of IL-1 beta and TNF-alpha synergistically enhanced the secretion of IL-8, whereas IFN-gamma suppressed IL-8 secretion by IL-1 beta- or
TNF-alpha stimulated
HGF
Takigawa et al., J Periodontol 1994
:
IL-6 secretion from either IL-1 beta- or
TNF-alpha stimulated
HGF was enhanced by the inhibition of PGE2 synthesis with indomethacin
Yano et al., Biochem Biophys Res Commun 1997
(Hepatoblastoma...) :
Although HGF did not detectably influence the proliferation or morphology of HMC-1 cells,
HGF inhibited the cells ' ability to release
tumor necrosis factor-alpha (TNF-alpha) in response to stimulation with PMA and the calcium ionophore, A23187
Gohda et al., J Cell Physiol 1998
(Leukemia) :
Out of phorbol 12-myristate 13-acetate ( PMA ), cholera toxin, IL-1 beta, and tumor necrosis factor (TNF)-alpha, the former three were as effective as IFN-gamma in KG-1 cells, but only
TNF-alpha stimulated
HGF/SF production in RPMI-8226 cells, whose effect was less than those of IFN-alpha, IFN-beta, and IFN-gamma
Hirano et al., J Periodontal Res 1997
:
In vitro stimulation by IL-1 beta,
TNF alpha or phorbol 12-myristate 13-acetate
induced an increase in total CD44 messenger RNA in
HGF but not change in overall patterns of CD44 isoform expression