Gene interactions and pathways from curated databases and text-mining

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TNF — TRAF2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Baud et al., Genes Dev 1999 : TNF-alpha also enhances the binding of native TRAF2 to MEKK1 and stimulates the kinase activity of the latter
Pryhuber et al., Am J Respir Cell Mol Biol 2000 (Pneumonia) : In contrast to the epithelial cells, TRAF1 was not induced by TNF-alpha in U937 cells, a human monocytic cell line, suggesting cell type-specific regulation
Caunt et al., J Biol Chem 2001 : Ras controls tumor necrosis factor receptor associated factor ( TRAF)6 dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components
Li et al., Nature 2002 : Moreover, E3-defective c-IAP1 prevented TNF-alpha induced TRAF2 degradation and inhibited apoptosis
Park et al., J Biol Chem 2003 (Hepatitis C) : Both TNF-alpha- and TRAF2 mediated nuclear factor-kappaB (NF-kappaB) activations were inhibited by NS5A-TRAF2 interaction
Yoshizumi et al., Exp Cell Res 2004 : Ebselen inhibited TNF-alpha induced TNF receptor associated factor 2 (TRAF2)-ASK1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ), which is an upstream signaling molecule of JNK ... Ebselen inhibited TNF-alpha induced TNF receptor associated factor 2 (TRAF2)-ASK1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ), which is an upstream signaling molecule of JNK
Kilpatrick et al., Am J Physiol Cell Physiol 2004 : Thus delta-PKC and PI 3-kinase are positive regulators of TNF mediated association of TRAF2 and RIP with TNFR-1
Hentze et al., Hepatology 2004 : CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2 , FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Yang et al., Invest Ophthalmol Vis Sci 2005 : Overexpression of mutant IkappaB blocked TNF-alpha induced TRAF-1, TRAF-2 , c-IAP1, c-IAP2, c-FLIP, and A1 gene expression and downregulated TRAF-1 protein levels
Wu et al., EMBO J 2005 : Furthermore, Ubc6 co-localized with translocated TRAF2/c-IAP1 in the ER-associated compartment in vivo, and a catalytically inactive Ubc6 mutant inhibited TNF-alpha induced, TNF-R2 dependent TRAF2 degradation
Zhang et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for TNF induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling
Blackwell et al., Mol Cell Biol 2009 (Lymphoma) : Here, we demonstrate that TNF-alpha and cellular stresses induce TRAF2 phosphorylation at serine 11 and that this phosphorylation is required for the expression of a subset of NF-kappaB target genes
Li et al., Mol Cell 2009 : The combined data reveal that phosphorylation of TRAF2 plays a critical role in TNF signaling by directing the IKK complex to the membrane, promoting TRAF2 K63 linked ubiquitination, and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase
Sondarva et al., Cell Res 2010 : Furthermore the downstream target of MLK3, JNK was activated by TNF-alpha in a TRAF2 dependent manner
Zhang et al., Mol Biol Cell 2011 : Here we report that TNF-a and oxidative stress both induce TRAF2 phosphorylation at serines 11 and 55 and that this dual phosphorylation promotes the prolonged phase of IKK activation while inhibiting the prolonged phase of JNK activation
Reinhard et al., EMBO J 1997 : Tumor necrosis factor alpha induced activation of c-jun N-terminal kinase is mediated by TRAF2 ... Our findings show that : ( i ) TNF-RII is able to activate two members of the MAP kinase family : extracellular regulated kinase (ERK) and c-jun N-terminal kinase (JNK); (ii) TRAF2, a molecule that binds TNF-RII and associates indirectly with TNF-RI, is sufficient to activate JNK upon overexpression ; ( iii ) dominant negative TRAF2 blocks TNF alpha mediated JNK activation and ( iv ) TRAF2 signals the activation of JNK and NF-kappaB through different pathways
Min et al., J Immunol 1997 : These data suggest that TNF activates parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription
Nishitoh et al., Mol Cell 1998 : In untransfected mammalian cells, ASK1 rapidly associates with TRAF2 in a TNF dependent manner