◀ Back to TNF
TNF — TRAF2
Pathways - manually collected, often from reviews:
-
BioCarta sodd/tnfr1 signaling pathway:
SODD (BAG4)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta sodd/tnfr1 signaling pathway:
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
→
TRAF2
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
TNF/TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1-TNF)
→
TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
TNF/TNF R/TRAF2/ASK1/RIP complex (TNFRSF1A-TRAF2-MAP3K5-RIPK1-TNF)
→
TNF R (TNFRSF1A)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (active) (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 2 (CASP2)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
MAP4K2
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
FADD/Caspase 8 complex (CASP8-FADD)
(modification, activates)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
Caspase 8 (CASP8)
(modification, activates)
-
BioCarta tnf/stress related signaling:
SODD (BAG4)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRAF2
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TRADD
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
I-TRAF (TANK)
→
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta tnf/stress related signaling:
TNF-alpha/TNF R1/TRADD/RIP/RAIDD/TRAF2/TANK/Caspase 2 complex (TRADD-TRAF2-TNF-CRADD-TANK-CASP2-RIPK1-TNFRSF1A)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
MADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRADD
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
TRAF2
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
SODD (BAG4)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
MADD
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RAIDD (CRADD)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/RIP/RAIDD/MADD/TRADD/TRAF2/cIAP complex (TNF-CRADD-TRAF2-BIRC3-TNFRSF1A-MADD-RIPK1-TRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta tnfr1 signaling pathway:
TNF-alpha/TNF R1/SODD complex (BAG4-TNFRSF1A-TNF)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRAF1
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
RAIDD (CRADD)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
SODD (BAG4)
→
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
cIAP2 (BIRC3)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TRAF2
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
Caspase 2 (CASP2)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
FADD
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNF R/Caspase 2/TNF/FADD/TRADD/RIP/cIAP/TRAF1/TRAF2/ASK1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-BIRC3-TRAF1-TRAF2-MAP3K5-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TRAF2
→
TNF/TNF R/SODD complex (TNF-BAG4-TNFRSF1A)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
TAK1/TAB family complex (MAP3K7-TAB2_TAB1)
(modification, collaborate)
Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
RAIDD (CRADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FADD (FADD)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
ASK1 (MAP3K5)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TRAF1 (TRAF1)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
cIAP2 (BIRC3)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
BAG4 (BAG4)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
Caspase 2 (CASP2)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/BAG4/TNF-alpha complex (TNF-BAG4-TNFRSF1A)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRADD (TRADD)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
RIP (RIPK1)
(modification, collaborate)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
TRAF2 (TRAF2)
(modification, collaborate)
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
FADD (FADD)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Atypical PKCs (PRKCI/PRKCZ)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Atypical PKCs (PRKCI/PRKCZ)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
p62 (SQSTM1)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
p62 (SQSTM1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
(modification, collaborate)
Sanz et al., EMBO J 1999
Evidence: physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
FADD/Caspase 8 complex (CASP8-FADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
Boldin et al., Cell 1996, Muzio et al., Cell 1996
Evidence: assay
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
NIK (MAP3K14)
(modification, activates)
Malinin et al., Nature 1997
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
STAT1 (STAT1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF)
→
MEKK3 (MAP3K3)
(modification, collaborate)
Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
RFFL (RFFL)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
RIP (RIPK1)
(modification, collaborate)
Liao et al., Curr Biol 2008
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
TRX/ASK1 complex (MAP3K5-TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
→
thioredoxin (TXN)
(modification, activates)
Ichijo et al., Science 1997, Saitoh et al., EMBO J 1998, Nishitoh et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caveolin-1 (CAV1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(translocation, activates)
Schütze et al., J Biol Chem 1999, D'Alessio et al., Am J Pathol 2005
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved) complex (TNFRSF1B-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Rothe et al., Cell 1994*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved) complex (TNFRSF1B-TNF)
→
TRAF1/TRAF2 complex (TRAF1-TRAF2)
(modification, collaborate)
Rothe et al., Cell 1994*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
TRAF1/TRAF2 complex (TRAF1-TRAF2)
(modification, collaborate)
Rothe et al., Cell 1994*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/p62/Atypical PKCs complex (TNFRSF1A-TRADD-RIPK1-TRAF2-SQSTM1-PRKCI_PRKCZ-TNF)
→
NF kappa B1/RelA complex (NFKB1-RELA)
(modification, activates)
Sanz et al., EMBO J 1999, Leitges et al., Mol Cell 2001
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RIP (RIPK1)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RIP (RIPK1)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
A20 (TNFAIP3)
(modification, collaborate)
Wertz et al., Nature 2004, Song et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
None
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, inhibits)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Neutral sphingomyelinase II (SMPD3)
(modification, activates)
Wiegmann et al., J Biol Chem 1999, Kolmakova et al., Arterioscler Thromb Vasc Biol 2004, Schwandner et al., J Biol Chem 1998
-
NCI Pathway Database Ceramide signaling pathway:
Cathepsin D/ceramide complex (CTSD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Heinrich et al., Cell Death Differ 2004
Evidence: assay
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/FAN complex (TNF-TNFRSF1A-NSMAF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database Ceramide signaling pathway:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
→
Acid Sphingomyelinase (SMPD1)
(modification, activates)
Testai et al., J Neurosci Res 2004, Takeshita et al., J Oral Sci 2005
Evidence: assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP1 (BIRC2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
cIAP2 (BIRC3)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP1 (BIRC2)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
cIAP2 (BIRC3)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2 complex (TNFRSF1B-TRAF1-TRAF2-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
TNF-alpha/TNFR2 (cleaved)/TRAF1/TRAF2/cIAP1/cIAP2 complex (TNFRSF1B-TRAF1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
TRAF2 (TRAF2)
(modification, collaborate)
Li et al., Nature 2002, Fotin-Mleczek et al., J Cell Sci 2002, Shu et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF)
→
IKK complex complex (CHUK-IKBKB-IKBKG)
(modification, activates)
Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, activates)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
Caspase 8 (CASP8)
→
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
(modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/cIAP1/cIAP2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-BIRC2-BIRC3-TNF)
→
Caspase 8 (tetramer) complex (CASP8)
(modification, inhibits)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Boldin et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD/PIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF-PIDD1)
→
Caspase 2 (CASP2)
(modification, activates)
-
NCI Pathway Database Ceramide signaling pathway:
cIAP2 (BIRC3)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRAF2 (TRAF2)
→
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRAF2 (TRAF2)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
BAG4 (BAG4)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RAIDD (CRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TRADD (TRADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
RIP (RIPK1)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
MADD (MADD)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
NCI Pathway Database Ceramide signaling pathway:
TNFR1A/BAG4/TNF-alpha complex (TNFRSF1A-BAG4-TNF)
→
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP/TRAF2/RAIDD complex (TRADD-MADD-BIRC3-RIPK1-TRAF2-CRADD-TNFRSF1A-TNF)
(modification, collaborate)
-
Reactome Reaction:
TNF
→
TRAF2
(reaction)
Harper et al., J Biol Chem 2003*, Micheau et al., Cell 2003, Hsu et al., Cell 1995
-
Reactome Reaction:
TNF
→
TRAF2
(indirect_complex)
Hsu et al., Cell 1995
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
Complex of TNFRSF1B-XPNPEP3-FANCD2-TNF-TRAF2
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Biogrid Interaction:
TNF
—
TRAF2
(physical association, affinity chromatography technology)
Micheau et al., Cell 2003
-
IRef Biogrid Interaction:
TNF
—
TRAF2
(physical association, affinity chromatography technology)
Kuai et al., J Biol Chem 2004*
-
IRef Biogrid Interaction:
TNF
—
TRAF2
(physical association, affinity chromatography technology)
Haas et al., Mol Cell 2009
-
IRef Biogrid Interaction:
TNF
—
TRAF2
(physical association, affinity chromatography technology)
Ea et al., Mol Cell 2006
-
IRef Hprd Interaction:
TNF
—
TRAF2
(in vitro)
Mukai et al., J Mol Biol 2009*, Schall et al., Cell 1990*, Torre-Amione et al., Circulation 1995*
-
IRef Hprd Interaction:
TNF
—
TRAF2
(in vivo)
Mukai et al., J Mol Biol 2009*, Schall et al., Cell 1990*, Torre-Amione et al., Circulation 1995*
-
IRef Hprd Interaction:
TNF
—
TRAF2
(in vivo)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of BIRC2-RIPK1-TRADD-TNFRSF1A-TNF-TRAF2
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of 11 proteins
(association, anti tag coimmunoprecipitation)
Micheau et al., Cell 2003
-
IRef Intact Interaction:
Complex of BIRC3-TNF-BIRC2-TRAF2-TRADD
(association, anti tag coimmunoprecipitation)
Jennewein et al., Oncogene 2012
Text-mined interactions from Literome
Baud et al., Genes Dev 1999
:
TNF-alpha also
enhances the binding of native
TRAF2 to MEKK1 and stimulates the kinase activity of the latter
Pryhuber et al., Am J Respir Cell Mol Biol 2000
(Pneumonia) :
In contrast to the epithelial cells,
TRAF1 was not
induced by
TNF-alpha in U937 cells, a human monocytic cell line, suggesting cell type-specific regulation
Caunt et al., J Biol Chem 2001
:
Ras controls
tumor necrosis factor receptor associated factor (
TRAF)6 dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components
Li et al., Nature 2002
:
Moreover, E3-defective c-IAP1 prevented
TNF-alpha induced
TRAF2 degradation and inhibited apoptosis
Park et al., J Biol Chem 2003
(Hepatitis C) :
Both
TNF-alpha- and TRAF2 mediated nuclear factor-kappaB (NF-kappaB) activations were
inhibited by
NS5A-TRAF2 interaction
Yoshizumi et al., Exp Cell Res 2004
:
Ebselen inhibited
TNF-alpha induced
TNF receptor associated factor 2 (TRAF2)-ASK1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ), which is an upstream signaling molecule of JNK ... Ebselen inhibited
TNF-alpha induced TNF receptor associated factor 2
(TRAF2)-ASK1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK1 ), which is an upstream signaling molecule of JNK
Kilpatrick et al., Am J Physiol Cell Physiol 2004
:
Thus delta-PKC and PI 3-kinase are positive regulators of
TNF mediated association of
TRAF2 and RIP with TNFR-1
Hentze et al., Hepatology 2004
:
CPT treatment completely abrogated the
TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors
TNF-receptor associated factor 2 , FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also
inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Yang et al., Invest Ophthalmol Vis Sci 2005
:
Overexpression of mutant IkappaB blocked
TNF-alpha induced TRAF-1,
TRAF-2 , c-IAP1, c-IAP2, c-FLIP, and A1 gene expression and downregulated TRAF-1 protein levels
Wu et al., EMBO J 2005
:
Furthermore, Ubc6 co-localized with translocated TRAF2/c-IAP1 in the ER-associated compartment in vivo, and a catalytically inactive Ubc6 mutant
inhibited TNF-alpha induced, TNF-R2 dependent
TRAF2 degradation
Zhang et al., J Biol Chem 2007
(MAP Kinase Signaling System) :
Our results demonstrate that RIP1 mediated AIP1 phosphorylation at the 14-3-3 binding site Ser-604 is essential for
TNF induced
TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling
Blackwell et al., Mol Cell Biol 2009
(Lymphoma) :
Here, we demonstrate that
TNF-alpha and cellular stresses
induce TRAF2 phosphorylation at serine 11 and that this phosphorylation is required for the expression of a subset of NF-kappaB target genes
Li et al., Mol Cell 2009
:
The combined data reveal that phosphorylation of
TRAF2 plays a critical role in
TNF signaling by directing the IKK complex to the membrane, promoting TRAF2 K63 linked ubiquitination, and positioning the IKKalpha and IKKbeta chains with the TAK1/TAB kinase
Sondarva et al., Cell Res 2010
:
Furthermore the downstream target of MLK3, JNK was activated by
TNF-alpha in a
TRAF2 dependent manner
Zhang et al., Mol Biol Cell 2011
:
Here we report that
TNF-a and oxidative stress both
induce TRAF2 phosphorylation at serines 11 and 55 and that this dual phosphorylation promotes the prolonged phase of IKK activation while inhibiting the prolonged phase of JNK activation
Reinhard et al., EMBO J 1997
:
Tumor necrosis factor alpha induced activation of c-jun N-terminal kinase is
mediated by
TRAF2 ... Our findings show that : ( i ) TNF-RII is able to activate two members of the MAP kinase family : extracellular regulated kinase (ERK) and c-jun N-terminal kinase (JNK); (ii) TRAF2, a molecule that binds TNF-RII and associates indirectly with TNF-RI, is sufficient to activate JNK upon overexpression ; ( iii ) dominant negative TRAF2 blocks
TNF alpha mediated JNK activation and ( iv )
TRAF2 signals the activation of JNK and NF-kappaB through different pathways
Min et al., J Immunol 1997
:
These data suggest that
TNF activates parallel
TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways to initiate E-selectin transcription
Nishitoh et al., Mol Cell 1998
:
In untransfected mammalian cells, ASK1 rapidly associates with
TRAF2 in a
TNF dependent manner