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AQP3 — EGF

Text-mined interactions from Literome

Cao et al., Biochem J 2006 : EGF ( epidermal growth factor ), which induced fibroblast migration, also induced AQP3 expression in a time- and dose dependent manner ... AQP3 knockdown by small interfering RNA inhibited EGF induced AQP3 expression and cell migration ... Furthermore, an EGFR ( EGF receptor ) kinase inhibitor, PD153035, blocked EGF induced AQP3 expression and cell migration ... MEK [ MAPK ( mitogen activated protein kinase ) /ERK ( extracellular-signal regulated kinase ) kinase ] /ERK inhibitor U0126 and PI3K ( phosphoinositide 3-kinase ) inhibitor LY294002 also inhibited EGF induced AQP3 expression and cell migration ... Collectively, our findings show for the first time that AQP3 is expressed in human skin fibroblasts and that EGF induces AQP3 expression via EGFR, PI3K and ERK signal transduction pathways
Ji et al., Cancer Chemother Pharmacol 2008 (Ovarian Neoplasms) : Curcumin attenuates EGF induced AQP3 up-regulation and cell migration in human ovarian cancer cells ... The results that curcumin inhibits EGF induced up-regulation of AQP3 and cell migration, provide a new explanation for the anticancer potential of curcumin