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CDC25A — CDK2

Pathways - manually collected, often from reviews:

• BioCarta cell cycle: g1/s check point: CDC25A → Cyclin E/CDK2 complex (CCNE1-CDK2) (modification, activates)
  
• BioCarta cyclins and cell cycle regulation: CDC25A → CYCLIN A/CDK2 complex (CDK2-CCNA1) (modification, activates)
  
• KEGG Cell cycle: CDC25A → CDK2 (protein-protein, dephosphorylation)
• KEGG Cell cycle: CDC25A → CDK2 (protein-protein, dephosphorylation)
• Reactome Reaction: CDK2 → CDC25A (reaction) Blomberg et al., Mol Cell Biol 1999*
• WikiPathways Cell Cycle: CDC25A → CDK2 (activation)
• WikiPathways Cell Cycle: CDC25A → CDK2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDC25A — CDK2 (direct interaction, enzymatic study) Cheng et al., BMC biochemistry 2005*
• IRef Biogrid Interaction: CDC25A — CDK2 (direct interaction, pull down) Xu et al., J Biol Chem 1996*
• IRef Hprd Interaction: CDC25A — CDK2 (in vitro) Qu et al., Am J Physiol Cell Physiol 2003*, Xu et al., J Biol Chem 1996*
• IRef Ophid Interaction: CDC25A — CDK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CDC25A — CDK2 (aggregation, confirmational text mining) Xu et al., J Biol Chem 1996*

Text-mined interactions from Literome

Blomberg et al., Mol Cell Biol 1999 : In vitro, Cdc25A dephosphorylates and activates the cyclin-Cdk complexes that are active during G ( 1 ) ... Overexpression of Cdc25A in the inducible system, however, leads to a premature activation of both cyclin E-Cdk2 and cyclin A-Cdk2 complexes, while no effect of cyclin D-dependent kinases is observed
Cangi et al., J Clin Invest 2000 (Breast Neoplasms) : Furthermore, in the breast cancer cell line MCF-7, Cdc25A activity is necessary for both the activation of Cdk2 and the subsequent induction of S-phase entry
Jaime et al., Hepatology 2002 : In conclusion, premature translocation of CDC25A to the nucleus might be involved in the advanced induction of cyclin E/CDK2 activity and DNA replication in cells from animals lacking p21 ( Cip1 )
Ducruet et al., J Biol Chem 2003 : Transfection with dominant negative Cdk mutants demonstrated that only a Cdk2 mutant increased Cdc25A protein levels ; Cdk1 and Cdk3 mutants had no effect
Koledova et al., Stem Cells 2010 : DNA damage induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells ... We hypothesize that Cdc25A degradation does not inhibit Cdk2 activity because a considerable proportion of Cdk2 molecules localize to the cytoplasm and centrosomes in mESCs, where they may be sheltered from regulation by nuclear Cdc25A
Lee et al., Invest Ophthalmol Vis Sci 2011 : Cdc25A inhibitor blocked activation of Cdk2 , phosphorylation of p27 at Thr187, and cell proliferation