Gene interactions and pathways from curated databases and text-mining

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IL2 — SP1

Text-mined interactions from Literome

Xiao et al., Eur J Immunol 1999 : FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 ... Our study identified a new FasL promoter site responding to IL-2 induced SP1 and NFAT factors
Martino et al., J Immunol 2001 : Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2 ... The enhancer element is bound constitutively by Sp1 and an unknown factor ( s ) and inducibly by Stat5 in response to IL-2
GarcĂ­a-Lora et al., Cancer Immunol Immunother 2001 : Here we report that PSK enhanced AP-1 and CRE binding activities, whereas IL-2 increased AP-1 and SP-1 and modified GAS/ISRE, IRF-1 and STAT5
Roman et al., New Biol 1990 : Sp1 represses IL-2 receptor alpha chain gene expression
Too et al., Mol Cell Endocrinol 1997 : Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells : differential association of Sp1-DNA complexes with Stats ... The induction of the transcription factor Sp1 by prolactin (PRL) and interleukin-2 (IL-2) was investigated in the PRL- and IL-2 responsive rat Nb2 T-cell line
Lin et al., Mol Cell Biol 1997 : Thus, Sp1 and Egr-1 physically and functionally cooperate to mediate maximal IL-2Rbeta promoter activity