Gene interactions and pathways from curated databases and text-mining

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CCND1 — IGF1R

Text-mined interactions from Literome

Carver et al., Mol Cancer Res 2008 (Breast Neoplasms...) : Moreover, prolactin increased cyclin D1 in the presence of the IGF-I receptor neutralizing antibody alphaIR3
Tsai et al., J Nutr Biochem 2011 (Neovascularization, Pathologic) : Western blotting and immunoprecipitation demonstrated that denbinobin causes more efficient inhibition of IGF-1 induced activation of IGF-1R and its downstream signaling targets, including, extracellular signal regulated kinase, Akt, mTOR, p70S6K, 4EBP and cyclin D1