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AHR — IL10
Text-mined interactions from Literome
Wilson et al., J Clin Invest 2007
(Asthma...) :
IL-10 also has paradoxical effects on Th2 associated pathology, with IL-10 deficiency resulting in increased Th2-driven inflammation but also
reduced airway hyperreactivity (AHR) , mucus hypersecretion, and fibrosis
Apetoh et al., Nat Immunol 2010
:
After T cell activation under Tr1 skewing conditions, the
AhR bound to c-Maf and
promoted transactivation of the
Il10 and Il21 promoters, which resulted in the generation of Tr1 cells and the amelioration of experimental autoimmune encephalomyelitis