◀ Back to CD4
CD4 — LEP
Text-mined interactions from Literome
MartÃn-Romero et al., Cell Immunol 2000
(Obesity) :
These results demonstrate the presence of the leptin receptor in human circulating
CD4 ( + ) and CD8 ( + ) T lymphocytes and a functional
role of
leptin as a modulator ( enhancer ) of lymphocyte stimulation with a shift toward Th1 cytokine production profile
Liu et al., J Immunol 2012
(Genetic Predisposition to Disease...) :
Leptin also
inhibits CD4 ( + ) CD25 ( + ) Foxp3 ( + ) regulatory T cells, which are known to contribute significantly to the mechanisms of peripheral immune tolerance