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CXCL1 — IL4
Text-mined interactions from Literome
Thomas et al., J Immunol 2004
(Bronchial Hyperreactivity) :
In lymphocytes restimulated with CXCL9 and allergen in vitro,
CXCL9 down-regulated
IL-4 expression and up-regulated IFN-gamma expression, suggesting that CXCL9 is able to direct activated lymphocytes toward a Th1-type phenotype
Méndez-Samperio et al., Mediators Inflamm 2006
:
We found that, although M. bovis BCG induced gene expression of CXCL-8 and CXCL-10 in M. bovis BCG infected human epithelial cells,
CXCL-8 mRNA level was significantly
reduced by
IL-4 , whereas no significant effect of IL-4 was observed on CXCL10 mRNA level ... Furthermore, we found a similar
effect of
IL-4 on M. bovis BCG induced
CXCL-8 and CXCL-10 secretion by using other human epithelial A549 cell line
Huang et al., Am J Physiol Lung Cell Mol Physiol 2007
:
IL-4 stimulates the expression of
CXCL-8 , E-selectin, VEGF, and inducible nitric oxide synthase mRNA by equine pulmonary artery endothelial cells
Ribaux et al., Endocrinology 2007
:
Induction of
CXCL1 by extracellular matrix and autocrine
enhancement by
interleukin-1 in rat pancreatic beta-cells
Byrne et al., PloS one 2013
(Airway Remodeling...) :
Furthermore, HDM or
IL-4 treatment of primary lung macrophages
resulted in significant production of both VEGF-A and
CXCL1 ; inhibition of HIF-1a activity abrogated the production of these factors via an up-regulation of PHD1 and PHD3