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IGF1 — JAK1

Text-mined interactions from Literome

Takahashi et al., Circ Res 1999 : These results indicated that ( 1 ) IGF-1 activated JAK1 but not JAK2 or Tyk2 in rat cardiomyocytes ; ( 2 ) IGF-1 induced both tyrosine and serine phosphorylation of STAT1 and STAT3 ; and ( 3 ) the tyrosine phosphorylation of STAT3 was not caused by JAK1 alone, and protein kinase C and intracellular Ca ( 2+ ) were required for phosphorylation
Gual et al., Endocrinology 1998 : Taking our data together, we conclude that : 1 ) insulin and IGF-1 lead to phosphorylation and activation of JAK-1 and JAK-2 in intact cells ; 2 ) phosphorylation of IRS-I by JAK-1 seems to occur on sites different from those phosphorylated by the insulin receptor ; 3 ) JAK-1 interacts directly with phosphorylated insulin and IGF-1 receptors ; and 4 ) the JH7-JH6 and JH1 domains of JAK-1 are responsible for the interaction with insulin and IGF-1 receptors