◀ Back to RARA

RARA — RXRA

Pathways - manually collected, often from reviews:

• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/p/CIP/PCAF/TIF2/GRIP1/SRC1/Retinoids complex (RXRA-RARA-NCOA3-PCAF-NCOA2-NCOA1) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (transcription, activates)
  
• BioCarta map kinase inactivation of smrt corepressor: RXR/RAR complex (RARA-RXRA) → SMRT (NCOR2) (transcription, activates)
• BioCarta degradation of the rar and rxr by the proteasome: RXR/RAR/Retinoid complex (RARA-RXRA) → RXR (RXRA) (modification, collaborate)
• BioCarta degradation of the rar and rxr by the proteasome: RXR/RAR/Retinoid complex (RARA-RXRA) → RAR (RARA) (modification, collaborate)
• BioCarta degradation of the rar and rxr by the proteasome: RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
• BioCarta degradation of the rar and rxr by the proteasome: RXR (RXRA) → RAR (RARA) (modification, collaborate)
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: HDAC3 → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: HDAC3 → RXR/RAR/HDAC3/NCOR2/SMRT complex (RXRA-RARA-HDAC3-NCOR2) (modification, collaborate)
  
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/Retinoid complex (RARA-RXRA) → RXR/RAR/HDAC3/NCOR2/SMRT complex (RXRA-RARA-HDAC3-NCOR2) (modification, collaborate)
  
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/Retinoid complex (RARA-RXRA) → SMRT (NCOR2) (modification, collaborate)
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/HDAC3/NCOR2/SMRT complex (RXRA-RARA-HDAC3-NCOR2) → SMRT (NCOR2) (modification, collaborate)
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/HDAC3/NCOR2/SMRT complex (RXRA-RARA-HDAC3-NCOR2) (modification, collaborate)
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/ACTR/RXR/CARM1/RAR/retinoids complex (CARM1-NCOA3-RXRA-RARA-CREBBP-EP300) → p300/CBP complex (CREBBP-EP300) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/ACTR/RXR/CARM1/RAR/retinoids complex (CARM1-NCOA3-RXRA-RARA-CREBBP-EP300) → CARM1 (modification, collaborate)
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/ACTR/RXR/CARM1/RAR/retinoids complex (CARM1-NCOA3-RXRA-RARA-CREBBP-EP300) → p/CIP (NCOA3) (modification, collaborate)
• BioCarta transcription regulation by methyltransferase of carm1: CBP/p300/ACTR/RXR/CARM1/RAR/retinoids complex (CARM1-NCOA3-RXRA-RARA-CREBBP-EP300) → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: p300/CBP complex (CREBBP-EP300) → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: CARM1 → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: p/CIP (NCOA3) → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta degradation of the rar and rxr by the proteasome: RXR/RAR/ubiquitin complex (RXRA-RARA) → RXR/RAR/Retinoid complex (RARA-RXRA) (protein ubiquitination, collaborate)
  
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/p/CIP/PCAF/TIF2/GRIP1/SRC1/Retinoids complex (RXRA-RARA-NCOA3-PCAF-NCOA2-NCOA1) → p/CIP/PCAF/TIF2/GRIP1/SRC1 complex (NCOA3-PCAF-NCOA2-NCOA1) (modification, collaborate)
  
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: RXR/RAR/p/CIP/PCAF/TIF2/GRIP1/SRC1/Retinoids complex (RXRA-RARA-NCOA3-PCAF-NCOA2-NCOA1) → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells: p/CIP/PCAF/TIF2/GRIP1/SRC1 complex (NCOA3-PCAF-NCOA2-NCOA1) → RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: RXR/RAR/Retinoid complex (RARA-RXRA) → RXR/RAR complex (RARA-RXRA) (modification, collaborate)
  
• BioCarta transcription regulation by methyltransferase of carm1: RXR/RAR/Retinoid complex (RARA-RXRA) (modification, collaborate)
• BioCarta transcription regulation by methyltransferase of carm1: RXR/RAR complex (RARA-RXRA) (modification, collaborate)
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RARs/VDR/DNA/Vit D3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-VDR) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RARs/VDR/DNA/Vit D3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-VDR) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RXRs (RXRB/RXRG/RXRB/RXRA) → RARs (RARA/RARG/RARB/RARB/RARB/RARG/RARB/RARA) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database RXR and RAR heterodimerization with other nuclear receptor: RARs (RARA/RARG/RARB/RARB/RARB/RARG/RARB/RARA) → RXRs/VDR/DNA/Vit D3 complex (RXRB_RXRG_RXRB_RXRA-VDR) (modification, collaborate)
  Kahlen et al., Biochem Biophys Res Commun 1994, Cheskis et al., Mol Cell Biol 1994, Schräder et al., J Biol Chem 1993
  Evidence: assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/9cRA/Cyclin H complex (RARA-CCNH-RXRA) → Rxr alpha (RXRA) (modification, collaborate) Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/9cRA/Cyclin H complex (RARA-CCNH-RXRA) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, collaborate)
  Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Rxr alpha (RXRA) → RAR alpha/9cRA/Cyclin H complex (RARA-CCNH) (modification, collaborate)
  Gaillard et al., Proc Natl Acad Sci U S A 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/RXRs complex (RARA-RXRB_RXRG_RXRB_RXRA) → RAR alpha (RARA) (modification, collaborate) Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/RXRs complex (RARA-RXRB_RXRG_RXRB_RXRA) → PKC alpha (PRKCA) (modification, collaborate) Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/RXRs complex (RARA-RXRB_RXRG_RXRB_RXRA) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha (RARA) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → NRIP1 (NRIP1) (transcription, activates) Kerley et al., Biochem Biophys Res Commun 2001, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → HDAC3 (HDAC3) (modification, collaborate) Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → RXRs/RARs/NRIP1/9cRA/HDAC1 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC1) (modification, collaborate)
  Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → HDAC1 (HDAC1) (modification, collaborate) Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → RXRs/RARs/NRIP1/9cRA/HDAC3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC3) (modification, collaborate)
  Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: HDAC3 (HDAC3) → RXRs/RARs/NRIP1/9cRA/HDAC1 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC1) (modification, collaborate)
  Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: HDAC3 (HDAC3) → RXRs/RARs/NRIP1/9cRA/HDAC3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC3) (modification, collaborate)
  Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA/HDAC1 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC1) → HDAC1 (HDAC1) (modification, collaborate) Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA/HDAC1 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC1) → RXRs/RARs/NRIP1/9cRA/HDAC3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC3) (modification, collaborate)
  Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: HDAC1 (HDAC1) → RXRs/RARs/NRIP1/9cRA/HDAC3 complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1-HDAC3) (modification, collaborate)
  Wei et al., J Biol Chem 2000, Gupta et al., Mol Cell Proteomics 2005, Augereau et al., Nuclear receptor signaling 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/RXRs complex (RARA-RXRB_RXRG_RXRB_RXRA) → RAR alpha (RARA) (modification, collaborate) Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/RXRs complex (RARA-RXRB_RXRG_RXRB_RXRA) → PKC gamma (PRKCG) (modification, collaborate) Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha/RXRs complex (RARA-RXRB_RXRG_RXRB_RXRA) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RAR alpha (RARA) → RXRs (RXRB/RXRG/RXRB/RXRA) (modification, collaborate)
  Delmotte et al., J Biol Chem 1999, Tahayato et al., Mol Endocrinol 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: NRIP1 (NRIP1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) (modification, activates)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) (modification, activates)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: Erk1-2-active (MAPK3/MAPK1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, activates)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → None (modification, collaborate) Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → SMRT (N-CoR2) (NCOR2) (modification, collaborate) Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs/NRIP1/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NRIP1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → None (modification, collaborate) Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → AKT1 (AKT1) (modification, collaborate) Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → SMRT (N-CoR2) (NCOR2) (modification, collaborate) Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: RXRs/RARs complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: None → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: AKT1 (AKT1) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, activates)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Retinoic acid receptors-mediated signaling: SMRT (N-CoR2) (NCOR2) → RXRs/RARs/SMRT(N-CoR2)/9cRA complex (RARA_RARG_RARB_RARB_RARB_RARG_RARB_RARA-RXRB_RXRG_RXRB_RXRA-NCOR2) (modification, collaborate)
  Hong et al., Mol Cell Biol 2000, Kerley et al., Biochem Biophys Res Commun 2001, Gupta et al., Mol Cell Proteomics 2005, Lefebvre et al., Mol Endocrinol 2006, Augereau et al., Nuclear receptor signaling 2006, Nagy et al., Mol Cell Biol 1995
  Evidence: mutant phenotype, assay, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: RXRA — RARA Bourguet et al., Mol Cell 2000*
• IRef Bind Interaction: RXRA — RARA Rastinejad et al., EMBO J 2000*
• IRef Bind_translation Interaction: RXRA — RARA (x-ray crystallography) Bourguet et al., Mol Cell 2000*
• IRef Bind_translation Interaction: RXRA — RARA (x-ray crystallography) Rastinejad et al., EMBO J 2000*
• IRef Bind_translation Interaction: RXRA — RARA (two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: RXRA — RARA (direct interaction, pull down) Benkoussa et al., Mol Cell Biol 2002*
• IRef Biogrid Interaction: RXRA — RARA (association, biochemical) Bugge et al., EMBO J 1992*
• IRef Biogrid Interaction: RXRA — RARA (physical association, affinity chromatography technology) Wu et al., J Mol Endocrinol 2004*
• IRef Biogrid Interaction: RXRA — RARA (association, x-ray crystallography) Pogenberg et al., J Biol Chem 2005*
• IRef Biogrid Interaction: RXRA — RARA (direct interaction, far western blotting) Li et al., Mol Endocrinol 1997*
• IRef Biogrid Interaction: RXRA — RARA (direct interaction, two hybrid) Albers et al., Mol Cell Proteomics 2005
• IRef Biogrid Interaction: RXRA — RARA (colocalization, imaging technique) Bellodi et al., J Biol Chem 2006*
• IRef Biogrid Interaction: RXRA — RARA (direct interaction, pull down) García-Fernández et al., Brain Res Mol Brain Res 1998*
• IRef Biogrid Interaction: RXRA — RARA (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• MIPS CORUM CBP-RARA-RXRA-DNA complex, ligand stimulated: CBP-RARA-RXRA-DNA complex, ligand stimulated complex (CREBBP-RARA-RXRA) Kamei et al., Cell 1996*
• IRef Corum Interaction: Complex of RXRA-RARA-CREBBP (association, electrophoretic mobility shift assay) Kamei et al., Cell 1996*
• IRef Dip Interaction: Complex of RARA-MED1-MED1-MED1-RARA-RARA-RXRA-RXRA-RXRA (physical association, molecular sieving) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: Complex of NCOA1-RXRA-RXRA-RARA-NCOA1-RARA (physical association, molecular sieving) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: RXRA — RARA (direct interaction, pull down) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: RXRA — RARA (direct interaction, cosedimentation in solution) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: RXRA — RARA (direct interaction, molecular sieving) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: RXRA — RARA (direct interaction, small angle neutron scattering) Rochel et al., Nature structural & molecular biology 2011*
• IRef Dip Interaction: RXRA — RARA (direct interaction, genetic interference) Seol et al., Mol Endocrinol 1995
• IRef Dip Interaction: RXRA — RARA (direct interaction, x ray scattering) Rochel et al., Nature structural & molecular biology 2011*
• IRef Hprd Interaction: RXRA — RARA (two hybrid) Rastinejad et al., EMBO J 2000*, Bourguet et al., Mol Cell 2000*, Kliewer et al., Nature 1992*, Albers et al., Mol Cell Proteomics 2005, Lee et al., EMBO J 2007
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Kamei et al., Cell 1996*
• IRef Intact Interaction: RXRA — RARA (direct interaction, x-ray crystallography) Rastinejad et al., EMBO J 2000*
• IRef Intact Interaction: RXRA — RARA (physical association, pull down) Huang et al., Cancer Cell 2009*
• IRef Intact Interaction: RXRA — RARA (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Ophid Interaction: RXRA — RARA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RXRA — RARA (aggregation, confirmational text mining) Rastinejad et al., EMBO J 2000*

Text-mined interactions from Literome

Zhu et al., Cancer Cell 2007 : PML/RARA enhances posttranslational modifications of RXRA , including its sumoylation, suggesting that PML bound sumoylation enzymes target RXRA and possibly other PML/RARA bound chromatin proteins, further contributing to deregulated transcription
Yamamoto et al., Blood 2010 (Leukemia, Promyelocytic, Acute...) : These included : ( 1 ) the same break point in RARA cDNA ; ( 2 ) self-association ; ( 3 ) retinoid X receptor alpha is necessary for BCOR-RARA to associate with the RARA responsive element ; ( 4 ) action in a dominant negative manner on RARA transcriptional activation ; and ( 5 ) aberrant subcellular relocalization
Um et al., J Biol Chem 1998 : In vitro, TDG enhanced RXR and RXR/RAR binding to their response elements