French et al., Am J Physiol Heart Circ Physiol 2006
(Myocardial Reperfusion Injury) :
Ischemia-reperfusion induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition
Randriamboavonjy et al., Circulation 2008
(Diabetes Mellitus, Type 2) :
In platelets from patients with type 2 diabetes mellitus, we found enhanced tyrosine nitration and inactivation of the sarcoplasmic endoplasmic reticulum Ca2+-ATPase ( SERCA-2 ), elevated platelet [Ca2+ ] i, and activation of mu-calpain