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ABL1 — MCL1
Text-mined interactions from Literome
Aichberger et al., Blood 2005
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
BCR/ABL dependent expression of
MCL-1 in Ba/F3 cells was counteracted by the mitogen activated protein-kinase/extracellular signal regulated kinase ( MEK ) inhibitor, PD98059, but not by the phosphoinositide 3-kinase inhibitor, LY294002
Kohl et al., Leukemia 2007
(Acute Disease...) :
In contrast to AML cell lines, BCR-ABL transformed human cells showed resistance to ABT-737, which might be due to the
induction of
MCL1 by
BCR-ABL
Li et al., Oncogene 2007
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Sphingosine kinase-1 mediates
BCR/ABL induced
upregulation of
Mcl-1 in chronic myeloid leukemia cells ... The signaling mechanisms responsible for
BCR/ABL induced regulation of
Mcl-1 expression in chronic myelogenous leukemia ( CML ) cells remain unclear ...
BCR/ABL also
induces upregulation of
Mcl-1 expression in CML cells ... Our data indicated that
BCR/ABL induces SPK1 expression and increases its cellular activity,
leading to upregulation of
Mcl-1 in CML cells
Allen et al., Blood 2011
(Leukemia, Lymphocytic, Chronic, B-Cell) :
c-Abl regulates
Mcl-1 gene expression in chronic lymphocytic leukemia cells