Gene interactions and pathways from curated databases and text-mining

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ADCY4 — CA2

Text-mined interactions from Literome

Kulikov et al., Biochemistry (Mosc) 1999 : 1-Alkenyl-PAF induced an increase in intracellular Ca2+ concentration and inhibition of adenylate cyclase at significantly higher concentrations than PAF
Nijjar et al., Int J Mol Med 2000 (Memory Disorders...) : Domoic acid induced neurodegeneration resulting in memory loss is mediated by Ca2+ overload and inhibition of Ca2+ + calmodulin stimulated adenylate cyclase in rat brain ( review )
Jurenka et al., Proc Natl Acad Sci U S A 1991 : Both forskolin and two cAMP analogues stimulated pheromone biosynthesis in the absence of extracellular Ca2+, indicating that Ca2+ may activate an adenylate cyclase
Tada et al., Eur J Pharmacol 1992 : Extracellular ATP has been shown to induce intracellular Ca2+ mobilization and adenylate cyclase inhibition via P2 purinoceptors in several species of cells
Yasui et al., Br J Dermatol 1992 : Beta-adrenergic agonists increase [Ca2+ ] i in cultured epidermal keratinocytes, and we have therefore studied whether stimulation of keratinocyte adenylate cyclase could induce [Ca2+ ] i increase, by using fluorescence microscopy with Fura 2-AM
Collier et al., Annu Rev Cell Dev Biol 2003 (Anthrax) : EF, a calmodulin- and Ca2+ dependent adenylate cyclase , is responsible for the edema seen in the disease
Cutler et al., Biochim Biophys Acta 1978 : It is suggested that the Ca2+ stimulated ATPase and adenylate cyclase activities in the dense tubules may possibly be involved in regulation of intracellular Ca2+ transport
Liu et al., Endocr Res 2004 (Diabetes Mellitus, Type 1) : Treatment with either agent abolished beta cell glucose sensitivity but insulin secretory responsiveness to a wide range of beta cell stimulators, including a depolarizing concentration of K+, elevation of Ca2+ and activation of adenylate cyclase and protein kinase C, were enhanced
Bruzzone et al., Biochem J 2006 : Here, we demonstrate that micromolar NAD+e ( both the alpha and the beta extracellular NAD+ forms ) induces a sustained [Ca2+ ] i increase in human granulocytes by triggering the following cascade of causally related events : ( i ) activation of adenylate cyclase and overproduction of cAMP ; ( ii ) activation of protein kinase A ; ( iii ) stimulation of ADP-ribosyl cyclase activity and consequent overproduction of cADP-ribose, a universal Ca2+ mobilizer ; and ( iv ) influx of extracellular Ca2+
Smith et al., Gut 1991 : Both basal ( IC50 = 193.75 ( 57.5 ) nmol/l ( mean ( SEM ) ) and NaF stimulated ( IC50 = 188.0 ( 44.0 ) nmol/l ) adenylate cyclase activity was strongly inhibited by free [Ca2+ ] greater than 90 nmol/l. Free [Ca2+ ] less than 90 nmol/l had no effect on adenylate cyclase activity ... These results suggest that human duodenal adenylate cyclase activity is calmodulin independent but is affected by changes in free [Ca2+ ]
Tada et al., Recent Adv Stud Cardiac Struct Metab 1976 : The inhibitory effect of Ca2+ on adenylate cyclase activity may represent a negative feedback mechanism by which eelevation of intracellular Ca2+ concentration lowers cellular levels of cyclic AMP and thus reduces Ca2+ influx into the myocardium
Bianchini et al., Biochim Biophys Acta 1990 : This adenylate cyclase is activated by Ca2+ and bovine brain or spinach calmodulin and it is inhibited by EGTA and some phenothiazine derivatives
Grasso et al., Endocrinology 1990 : Follicle stimulating hormone receptor mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase
Kusano et al., Am J Physiol 1985 : Added Ca2+ inhibited the AVP stimulated adenylate cyclase in MCT and MAL ( half-maximum approximately equal to 5 X 10 ( -4 ) M Ca2+ ) and stimulated cAMP phosphodiesterase ( cAMP-PDIE ) in both MCT and in MAL ( half-maximum approximately equal to 9 X 10 ( -5 ) M Ca2+ )
Chen et al., Endocrinology 1989 : Pertussis toxin pretreatment did not enhance adenylate cyclase activity indirectly via reducing the extracellular Ca2+ induced rise in cytosolic Ca2+, since the cytosolic Ca2+ level at 5 mM Ca2+ was about 60 % higher in pertussis toxin treated than in control cells ( 531 +/- 85 vs. 326 +/- 35 nM ; P less than 0.05 )
Harrison et al., J Biol Chem 1989 : The synergistic activation of adenylate cyclase by calmodulin and Gs was dependent on the presence of Ca2+ and occurred at physiologically relevant Ca2+ concentrations
Segal et al., Endocrinology 1989 : Since the effects of T3 on thymocyte adenylate cyclase activity, cAMP concentration, and 2-DG uptake occur subsequent to these effects on calcium metabolism and require the presence of Ca2+ in the extracellular fluid, we suggest that an increase in [ Ca2+ ] i, due at least partly to an influx of extracellular calcium, is the initiating event in these plasma membrane mediated responses of the rat thymocyte to T3
Mørk et al., Eur J Pharmacol 1989 : Serotonin ( 5-HT ) dose dependently reduced Ca2+ stimulated adenylate cyclase activity in the hippocampus, and chronic lithium administration reduced the ability of 1 microM 5-HT to inhibit Ca2+ stimulated enzyme activity ... Furthermore, the 5-HT induced GTP mediated inhibition of Ca2+ stimulated adenylate cyclase activity in the hippocampus was markedly decreased by lithium ... Increasing concentrations of dopamine in the striatum did not, however, affect Ca2+ stimulated adenylate cyclase activity and the inhibition of enzyme activity observed with increasing concentrations of GTP was not influenced by chronic lithium treatment ... These results demonstrate that lithium ex vivo exerts dual and region-specific effects on Ca2+ stimulated adenylate cyclase in the brain
Harrison et al., Biochemistry 1989 : Iodo-CaM-DAPs behaved like native CaM with respect to ( 1 ) Ca2+ dependent enhanced mobility on sodium dodecyl sulfate-polyacrylamide gels and ( 2 ) Ca2+ dependent stimulation of adenylate cyclase activity
Meller et al., Mol Cell Endocrinol 1988 : The data revealed that both larval and pupal prothoracic gland membrane fractions have a Ca2+/CaM dependent adenylate cyclase which is inhibited by CaM antagonists and EGTA
Bourne et al., Mol Cell Endocrinol 1988 : These results suggest that ( i ) the extracellular Ca2+ independent component of LH release is indirectly mediated by cAMP through the stimulation of de novo protein synthesis, and ( ii ) extracellular Ca2+ is required for the activation of adenylate cyclase in male but not in female gonadotrophs
Ferroni et al., Comp Biochem Physiol A Comp Physiol 1987 : 4. Since darkening responses promoted by cyclic nucleotides proceeded normally in the presence of verapamil and extracellular calcium was not necessary for melanotropin dispersing action, it is suggested that the blocking activity obtained with verapamil is probably due to an impairment of the Ca2+ dependent adenylate cyclase activity
Cooper et al., J Cell Biochem 1988 : Ca2+/calmodulin stimulated adenylate cyclase activity in EGTA washed plasma preparations from each region studied -- from 1.3-fold ( in striatum ) to 3.4-fold ( in cerebral cortex ) ... In EGTA washed membranes, receptor mediated inhibition of adenylate cyclase was strictly dependent upon Ca2+/calmodulin stimulation in all regions, except striatum
Behrman et al., Adv Prostaglandin Thromboxane Leukot Res 1985 : The increase in cytosolic Ca2+ inhibits adenylate cyclase activity by blocking GTP dependent activation of adenylate cyclase
Segal et al., Endocrinology 1985 : In the presence of 1 microM Ca+2 , T3 induced a time dependent increase in adenylate cyclase activity that was statistically significant between 1 and 2 min and maximum between 2 and 5 min after hormone addition
Allen et al., Biochem Pharmacol 1986 : It is concluded the Ca2+ is required for the interaction of ACTH with its receptor and the resultant activation of adenylate cyclase
Rossi et al., Life Sci 1987 : Ca chelation blocks the inhibitory effect, consistent with mediation by increased intracellular free Ca2+, and it has been suggested that intracellular Ca2+ could increase as a result of receptor induced inhibition of adenylate cyclase followed by decreased Ca efflux from the renin secreting cells
Rao et al., Blood 1987 : These findings suggest that ADP induced Ca2+ mobilization and inhibition of adenylate cyclase are mediated by platelet binding sites distinct from those mediating shape change
Piascik et al., Am J Physiol 1986 : The effect of Ca2+ on the adenylate cyclase activity associated with membranes prepared from mouse parotid gland has been examined ... Ca2+ stimulated then inhibited adenylate cyclase activity, with values for half-maximal stimulation and inhibition of 0.6 and 10 microM, respectively ... Exogenous calmodulin restored the ability of Ca2+ to stimulate the adenylate cyclase activity associated with EGTA treated membranes ... These data indicate that calmodulin mediates the activation of parotid gland adenylate cyclase by Ca2+ and that Ca2+ , at concentrations which stimulate and inhibit amylase secretion, can activate and inhibit adenylate cyclase activity
Dudai et al., J Comp Physiol A 1988 : What is the possible contribution of Ca2+ stimulated adenylate cyclase to acquisition, consolidation and retention of an associative olfactory memory in Drosophila
Motulsky et al., Am J Physiol 1988 (Leukemia, Erythroblastic, Acute) : Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells
Ahlijanian et al., Cell Mol Neurobiol 1988 : Ca2+/calmodulin stimulated striatal and hippocampal adenylate cyclase activity by 1.4- and 2.7-fold respectively, while dopamine and vasoactive intestinal peptide (VIP) stimulated the enzyme activity of these respective regions by 1.3- and 2-fold
Feng et al., Andrologie 1988 : In view of these facts, we suggest that the `` hyperactivated motility '' which membrane-intact spermatozoa display upon capacitation may be due to the activation of a Ca2+ dependent adenylate cyclase ( and the resultant increase in intracellular cAMP ), rather than being a direct effect of a rise in the intracellular Ca2+ concentration
Bissen et al., Neurochem Res 1986 : The subcellular distribution of Ca2+/calmodulin stimulated adenylate cyclase activity was studied in comparison with that of guanine nucleotide stimulated cyclase activity
Resink et al., Eur J Biochem 1986 : Membrane fractions, prepared by washing in the presence of LaCl3 to remove endogenous calmodulin ( approximately equal to 70-80 % depletion ), exhibited no stimulation of adenylate cyclase by Ca2+ but did show the inhibitory phase ( Ki = 0.4 microM )
Peake et al., Endocrinology 1985 : We examined the roles of CaM, Mg+2, and Ca+2 in the regulation of adenylate cyclase activity in plasma membranes from anterior pituitary
Piascik et al., Life Sci 1985 (Substance-Related Disorders) : Ca2+ activated then inhibited the adenylate cyclase activity associated with a 20,000 X g particulate fraction from pentobarbital dependent and age matched control rats
Piascik et al., Arch Biochem Biophys 1985 : Ca2+ dependent inhibition of smooth muscle adenylate cyclase activity ... We have examined the inhibitory regulation by Ca2+ of the adenylate cyclase activity associated with microsomes isolated from bovine aorta smooth muscle ... These data show that ( i ) Ca2+ , at concentrations similar to those which activate smooth muscle contraction, inhibits the stimulation of adenylate cyclase by several activators ; ( ii ) Ca2+ and Mg2+ compete for a common site on the smooth muscle adenylate cyclase complex ; and ( iii ) the reversal of Ca2+ dependent inhibition by Ca2+ binding proteins may be produced by chelation of the metal by these proteins
Mac Neil et al., Biochem J 1984 (Melanoma) : Half-maximal stimulation of agonist-responsive adenylate cyclase occurred at 80 nM-calmodulin in the presence of 10 microM free Ca2+
Malnoë et al., Biochim Biophys Acta 1982 : Ca2+ dependent regulation of calmodulin binding and adenylate cyclase activation in bovine cerebellar membranes ... On the basis of this model, a quantitative analysis of the effect of free Ca2+ and of free calmodulin concentration on both binding and activation of adenylate cyclase was carried out
Gnegy et al., Fed Proc 1982 : In vitro studies have demonstrated that CaM and Ca2+ can stimulate basal adenylate cyclase activity in a striatal particulate fraction as well as increase the sensitivity of the enzyme to dopamine ... Ca2+ and CaM most likely affect the dopamine-sensitive adenylate cyclase by interacting with guanyl nucleotides, which are required for dopamine sensitivity
Nagao et al., Biochem Pharmacol 1983 : The inhibitions of the adenylate cyclase activity by these agents were dose dependent and not Ca2+ dependent
Wilkening et al., Brain Res 1980 (Glioma...) : Activation of either opiate receptors by 10 microM morphine or alpha-adrenergic receptors by 10 microM norepinephrine inhibits adenylate cyclase by 55 % in the absence of Ca2+ ions, and inhibits the Ca2+ dependent activation of adenylate cyclase by more than 90 %
Sharp et al., Diabetes 1980 : Stimulation of adenylate cyclase by Ca2+ and calmodulin in rat islets of langerhans : explanation for the glucose induced increase in cyclic AMP levels
Voorheis et al., Eur J Biochem 1980 : The ability of Ca2+ to stimulate adenylate cyclase is lost upon rupture of the cell, which is reminiscent of the loss of control of the adenylate cyclase in Escherichia coli by sugars of the phosphotransferase system when cell breakage occurs ... The physiological function of the Ca2+ activation of adenylate cyclase in T. brucei has not been established but a possible role in the change of surface coat in bloodstream forms should be considered
Potter et al., Ann N Y Acad Sci 1980 : The fact that Ca2+ still regulates adenylate cyclase after various stimuli ( histamine, NaF, etc. ) suggests that Ca2+ may function to regulate the cyclase over shorter time periods ( regardless of its state of stimulation ) and that other affectors of cyclase ( e.g., hormones ) would serve to regulate the cyclase over longer time periods
Sano et al., J Neurochem 1981 : Fractions containing the guanylnucleotide-sensitive activity were found to contain a factor that inhibited basal and Ca2+ stimulated adenylate cyclase in the Ca2+-sensitive fraction
Bellorin-Font et al., Am J Physiol 1981 : These studies examine the interactions of Ca2+ , Mg2+, and guanine nucleotides with PTH binding to renal receptors and activation of adenylate cyclase in a purified preparation of basolateral renal cortical membranes
Bellorin-Font et al., Am J Physiol 1982 : Substitution of Mg2+ by Mn2+ abolished the inhibitory effect of Ca2+ on basal adenylate cyclase activity
Brostrom et al., J Biol Chem 1982 (Glioma...) : Cell free preparations of control and PMA treated cultures did not differ significantly in calmodulin content or in Ca2+ stimulated adenylate cyclase , Ca2+ dependent cAMP phosphodiesterase, and ( Ca2+-Mg2+ ) -ATPase activities
Greenlee et al., Biochemistry 1982 : However, the concentration of CaM required for half-maximal stimulation of B. pertussis adenylate cyclase in the presence of 1 nM free Ca2+ was 24 nM
Gordon et al., Biochim Biophys Acta 1983 : Arrhenius-type plots of S indicated that the lipid phase separation, present in the external leaflet of native membranes between 28 and 19 degrees C, is perturbed by mM Ca2+ such that the high temperature onset is elevated to 32-34 degrees C. Fluoride stimulated adenylate cyclase was similarly inhibited by Ca2+ ( ID50 = 1 mM ) for the enzyme in membrane bound or solubilized states
Mahaffee et al., Mol Pharmacol 1983 : Ca2+ increases both the rate of reversible nucleotide binding and the rate of adenylate cyclase activation by nucleotide
Girardot et al., J Neurochem 1983 : These results suggest that calmodulin is involved in both Ca2+ stimulation and guanine nucleotide mediated inhibition of rat hippocampal adenylate cyclase
Gnegy et al., J Neurosci 1984 : CaM stimulated adenylate cyclase activity in washed particulate fractions of bovine retina by 6.6-fold in a Ca2+ dependent manner
Sulimovici et al., Arch Biochem Biophys 1984 : In the presence of free Ca2+ , calmodulin increased the specific activity of the calmodulin-sensitive adenylate cyclase from 15.2 to 60.4 pmol/mg protein-1 min-1
Severin et al., Biokhimiia 1983 : Using a membrane preparation of striatal adenylate cyclase possessing a high sensitivity to calmodulin, the effects of fatty acids on regulation of adenylate cyclase by Ca2+ and calmodulin were studied
Thams et al., Biochem J 1982 : Differential effects of Ca2+-calmodulin on adenylate cyclase activity cyclase activity in mouse and rat pancreatic islets ... The effects of Ca2+-calmodulin on adenylate cyclase activity in EGTA washed, 27000 g particulate fractions of mouse and rat pancreatic islets were studied ... Trifluoperazine ( 50 microM ), a specific inhibitor of calmodulin, inhibited the Ca2+-calmodulin activation of the adenylate cyclase activity of this fraction of rat islets
Voorheis et al., Eur J Biochem 1981 : 1. The adenylate cyclase of bloodstream forms of Trypanosoma brucei is regulated by Ca2+
Brostrom et al., Biochim Biophys Acta 1982 (Pituitary Neoplasms) : Trifluoperazine inhibited adenylate cyclase of GH3 cells only in the presence of Ca2+ ; as Ca2+ concentrations in the assay were increased, higher drug concentrations were required to inhibit the enzyme
Rybicki et al., Biochim Biophys Acta 1983 : Addition of prostaglandin H2 ( 0.3 microM ) to the platelet vesicles produced a significant release of Ca2+ only in the presence of the adenylate cyclase inhibitor, 2',5'-dideoxyadenosine ( 100 microM )
Piascik et al., J Biol Chem 1983 : The Ca2+ dependent regulation of the adenylate cyclase activity associated with microsomes isolated from bovine aortic smooth muscle has been studied ... In the presence of 5 or 9 microM bovine testis calmodulin, Ca2+ stimulated smooth muscle adenylate cyclase activity with one-half-maximal stimulation occurring at 0.2 microM for both 5 and 9 microM calmodulin
Pinchasi et al., J Neurochem 1982 : The Torpedo adenylate cyclase is completely inhibited by low levels of free Ca2+ ( KD approximately 0.5 microM )
Houchi et al., Life Sci 1995 : Forskolin, an activator of adenylate cyclase , also stimulated the efflux of 45Ca2+ from the cells
Nishigaki et al., Mol Pharmacol 1996 : The EP1 and EP3 receptors are coupled to Ca2+ mobilization and the inhibition of adenylate cyclase , respectively, and the EP2 and EP4 receptors are coupled to the same signal transduction pathway, stimulation of adenylate cyclase
Hanski et al., Eur J Biochem 1977 : The Mn2+ supported adenylate cyclase is not inhibited by Ca2+ as was found for the native membrane bound enzyme
Nakahara et al., J Pineal Res 1997 : This direct evidence strongly supports the hypothesis that cAMP dependent protein kinase A may be involved in the subjective nocturnal increase in melatonin release by chick pineal cells and that intracellular Ca2+ plays an important role in pineal adenylate cyclase activation
Zondag et al., Biochem J 1998 : Sphingosine 1-phosphate ( S1P ) and lysophosphatidic acid (LPA) are structurally related lipid mediators that act on distinct G-protein coupled receptors to evoke similar responses, including Ca2+ mobilization, adenylate cyclase inhibition , and mitogen activated protein ( MAP ) kinase activation
Okamoto et al., J Biol Chem 1998 : EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen activated protein kinase activation, and adenylate cyclase inhibition
Nikaido et al., J Biol Rhythms 1998 : These results suggest that the rhythm of cAMP in chick pineal cells involves the stimulation of adenylate cyclase by Ca2+/calmodulin during the night and a GTP dependent suppression of adenylate cyclase activity during the day