Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Whitacre et al., Clin Cancer Res 2000 (Colonic Neoplasms) : Our results suggest that : ( a ) Pc 4-PDT is effective in the treatment of SW480 human colon cancer xenografts independent of p53 status ; ( b ) PARP cleavage may be mediated by caspase-9 and caspase-3 activation in the Pc 4-PDT treated tumors ; and ( c ) p38 phosphorylation may be a trigger of apoptosis in response to PDT in vivo in this tumor model
McLaughlin et al., J Neurosci 2001 : Indeed, an early robust increase in TEA-sensitive potassium channel currents induced by DTDP is attenuated by p38 inhibition but not by caspase inhibition
Baudhuin et al., Mol Pharmacol 2002 : LPA/S1P induced Akt activation may be involved in cell survival, because LPA and S1P treatment in HEY ovarian cancer cells results in a decrease in paclitaxel induced caspase-3 activity in a PI3-K/MEK/p38 dependent manner
Tuo et al., Life Sci 2004 (MAP Kinase Signaling System) : The opposing effects of onychin on phosphorylation levels of p38MAPK and ERK1/2, and its caspase-3 inhibition might play a role in the beneficial effect of onychin on endothelial injury
Guo et al., World J Gastroenterol 2005 : Since p38 phosphorylation induced by TGF-beta1 plays an important role in caspase activation and apoptosis, TPA and EGF induced p38 phosphorylation may not be requisite for their anti-apoptotic function
Shih et al., Food Chem Toxicol 2005 (Adenocarcinoma...) : In addition, the malvidin treatment significantly increased the p38 kinase expression and inhibited the ERK activity, and the effects of malvidin on caspase-3 activation were blocked , respectively, by the ERK and p38 inhibitors
Friis et al., J Physiol 2005 (Mechanotransduction, Cellular) : Inhibition of p38 in Rac cells reduced the activation of both p53 and caspase-3
Singh et al., Neuroscience 2005 (Nerve Degeneration) : Tat induced increases in caspase-3 activity were significantly attenuated by an inhibitor of c-jun-N-terminal kinase ( anthra [ 1,9-cd ] pyrazol-6 ( 2H ) -one ), but not by an inhibitor of p38 ( [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsul-finylphenyl ) -5- ( 4-pyridyl ) 1 H-imidazole ] ), mitogen activated protein kinase
Baek et al., Biol Pharm Bull 2006 (Osteoarthritis) : Also, Aralia cordata inhibited the chondrocyte apoptosis through the downregulation of JNK and p38 MAP kinase signal, and the inhibition of caspase-3 activity
Hormi-Carver et al., Am J Physiol Gastrointest Liver Physiol 2007 (Barrett Esophagus...) : Inhibition of p38 also prevented expression of cleaved caspase-3 , suggesting that ATRA activates p38 upstream of the caspase cascade
Ohta et al., J Cell Physiol 2007 (Anoxia...) : Inhibition of p38 suppressed activation of caspase-3 but not vice versa
Fan et al., Mol Cells 2007 : Suppression of p38 activation by SB203580 reduced the extent of apoptosis of the HeLa cells and also prevented induction of p21, release of cytochrome c, and cleavage of caspase-3 and PARP
Park et al., Exp Mol Med 2007 : Although 6-OHDA increased phosphorylation of p38 was prevented by NAC or BAPTA, inhibition of p38 by SB203580 did not suppress ROS, Bax/Bcl-2 ratio, or caspase-3 activity increases , and only partially prevented 6-OHDA induced cell death, thus demonstrating that p38 activation is a component of a signaling pathway leading to the initiation of 6-OHDA induced cell death, which acts in parallel with an ROS-Ca ( 2+ ) -Bcl-2-caspase-3 pathway
Roesslein et al., Anesth Analg 2008 (Inflammation) : Our data suggest that sevoflurane induced p38 activation is not affected by caspase activation
Mitsiades et al., Cancer Res 2008 (Multiple Myeloma) : Mechanistically, a short in vitro exposure to Aplidin induces MM cell death, which involves activation of p38 and c-jun NH ( 2 ) -terminal kinase signaling, Fas/CD95 translocation to lipid rafts, and caspase activation
Eguchi et al., Proteomics 2008 (Anoxia) : Although some of these proteins decreased after hypoxia, none of them met the conditions of being quantitatively restored by p38 inhibition but not by caspase inhibition
Lu et al., Clin Exp Pharmacol Physiol 2009 (Osteosarcoma) : 4. The results of the present study suggest that, in MG63 human osteosarcoma cells, desipramine causes Ca ( 2+ ) -independent apoptosis by inducing p38 MAPK associated activation of caspase 3
Walker et al., International journal of environmental research and public health 2010 (Lung Neoplasms) : Furthermore, arsenic trioxide modulated caspase 3 activity and induced p38 MAP kinase activation in A549 cells
Zhang et al., Environ Toxicol 2013 : Moreover, a JNK inhibitor, but not p38 inhibitor, significantly reduced caspase-3 activation
Bulzomi et al., J Cell Physiol 2012 : p38 activation is responsible for pro-apoptotic activation of caspase-3 and the cleavage of poly ( ADP-ribose ) polymerase