Gene interactions and pathways from curated databases and text-mining

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AIRE — MAPK4

Text-mined interactions from Literome

Nagafuchi et al., Immunol Lett 2005 (Epstein-Barr Virus Infections...) : In addition, the expression of AIRE gene was inhibited by specific p38 MAPK inhibitor ( SB203580 ), whereas the expression was rather enhanced by the MEK1/2 inhibitor ( U0126 ), suggesting that AIRE gene expression is regulated by mitogen activated protein kinase pathway
Nagafuchi et al., Microbiol Immunol 2006 (MAP Kinase Signaling System) : Mitogen activated protein kinases ( MAPKs ), including MAPK kinase ( MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor ( SB203580 ), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells