Gene interactions and pathways from curated databases and text-mining

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AKT2 — EDN1

Text-mined interactions from Literome

Rubin et al., J Appl Physiol 2005 : AMPK activation by N ( 2 ) -2DG was associated with a rapid and pronounced reduction in endothelin induced force and reduced phosphorylation of Akt and Erk 1/2
Morgan et al., Am J Respir Cell Mol Biol 2005 : Both MBP1 and EDN induced phosphorylation of Akt , but with divergent time courses and intensities, and survival was independent of Akt
Krüger et al., Circ Res 2008 : Also, angiotensin II, but not endothelin-1 or cell stretch, enhanced Akt phosphorylation
Herrera et al., J Biol Chem 2009 : Endothelin-1 stimulated Akt activity by 0.16 +/- 0.02 arbitrary units as measured by fluorescence resonance energy transfer ( p < 0.001 ; n = 5 ) and increased phosphorylation of Akt at Ser473 by 56 +/- 11 % ( p < 0.002 ; n = 7 )
Cianfrocca et al., Can J Physiol Pharmacol 2010 (Ovarian Neoplasms) : Beta-arrestin-1 mediates the endothelin-1 induced activation of Akt and integrin linked kinase