Gene interactions and pathways from curated databases and text-mining

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AKT2 — SMAD5

Text-mined interactions from Literome

Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Anhê et al., Mol Cell Endocrinol 2010 : Smad5 regulates Akt2 expression and insulin induced glucose uptake in L6 myotubes ... The present study indicates that Smad5 regulates glucose uptake in skeletal muscle by controlling Akt2 expression and phosphorylation
Sweetwyne et al., Am J Pathol 2010 : Collagen stimulation was independent of TGF-ß activity and Smad phosphorylation but was blocked by an Akt inhibitor, suggesting that signaling through the Akt pathway is important for regulation of collagen through TSP1 binding to calreticulin
Ueki et al., Glia 2013 : Interestingly, BMP/Smad1/5/8 activation downstream of PI3K/AKT signaling was also necessary for robust Müller glial proliferation, though activation of BMP/Smad1/5/8 signaling alone failed to stimulate their proliferation
Han et al., Int J Biochem Cell Biol 2013 : In addition, Smad activation inhibits muscle protein synthesis by suppressing Akt signaling