Moon et al., Cancer Lett 2010
(Carcinoma, Hepatocellular...) :
SFN also suppressed the phosphorylation of Akt ( Ser-473 ), thereby inhibiting hTERT phosphorylation and this effect was reversed by pretreatment with NAC
Roy et al., Journal of molecular signaling 2010
:
SFN inhibited phosphorylation of AKT and ERK, and activated FOXO transcription factors, leading to cell cycle arrest and apoptosis