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ANG — SMAD3
Text-mined interactions from Literome
Wang et al., Circ Res 2006
(Arteriosclerosis...) :
Finally, activation of Smad3 but not Smad2 was a key and necessary mechanism of Ang II-induced vascular fibrosis because
Ang II
induced Smad3/4 promoter activities and collagen matrix expression was abolished in VSMCs null for Smad3 but not Smad2
Lee et al., Nephrol Dial Transplant 2007
(Diabetes Mellitus, Experimental...) :
COMP-Ang1 also
reduced renal tissue levels of transforming growth factor-beta1 ( TGF-beta1 ), alpha-smooth muscle actin, fibronectin, as well as
Smad 2/3 expression, but increased Smad 7 expression
Yang et al., J Pathol 2010
(Kidney Diseases) :
In conclusion,
Ang II
activates Smad signalling to induce EMT, which is mediated by a loss of Smad7 through the AT1-Smurf2 dependent ubiquitin degradation pathway