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ANGPT1 — CASP3
Text-mined interactions from Literome
Harfouche et al., FASEB J 2003
(MAP Kinase Signaling System) :
The presence of
Ang-1 ( 300 ng/ml ) significantly attenuated endothelial cell apoptosis and
inhibited caspase-9 , -7, and -3 activation
Dallabrida et al., Circ Res 2005
(MAP Kinase Signaling System) :
Angiopoietin-1 promoted survival of serum starved C2C12, HSM, and NCM ( MTT, trypan blue ) and
prevented taxol induced apoptosis (
caspase-3 )
Parborell et al., Mol Cell Endocrinol 2011
:
Moreover,
ANGPT1 inhibition
increased the levels of
active caspase 3 and androsterone, but decreased estradiol, AKT phosphorylation and the area of smooth muscle cell actin
Lee et al., Mol Med 2011
(Myocardial Reperfusion Injury) :
Angiopoietin-1 increased cardiomyocyte survival through integrin-ß1 mediated extracellular signal regulated kinase ( ERK ) phosphorylation, which inhibited caspase-9 through phosphorylation at Thr1²5 and subsequently
reduced active caspase-3
Ren et al., Journal of biomedical research 2012
:
Specifically,
angiopoietin-1 prevented DOX induced increases in FasL and Bax levels and cleaved
caspase-3 and caspase-8 levels in H9C2 cells ... Specifically,
angiopoietin-1 prevented DOX induced increases in FasL and Bax levels and cleaved caspase-3 and
caspase-8 levels in H9C2 cells