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ATF2 — TNF
Text-mined interactions from Literome
Ivanov et al., J Biol Chem 1999
(Melanoma) :
At the same time, either truncated or full-length forms of
ATF2 reduced UVC induced activation of the
tumor necrosis factor-alpha (TNFalpha) promoter and decreased expression of TNFalpha
Brinkman et al., J Biol Chem 1999
:
The study presented here shows that autoregulation of
TNF-alpha gene transcription by selective signaling through tumor necrosis factor receptor 1 (TNFR1)
requires p38 mitogen activated protein ( MAP ) kinase activity and the binding of the transcription factors
ATF-2 and Jun to the TNF-alpha cAMP-response element ( CRE ) promoter element
Clerk et al., J Mol Cell Cardiol 1999
(MAP Kinase Signaling System) :
IL-1 beta and
TNF alpha stimulated the phosphorylation of c-Jun and
ATF2
Fuchs et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Treatment of cells with okadaic acid elevated the
tumor necrosis factor alpha
induced ATF2 level and the extent of its specific N-terminal phosphorylation
Ivanov et al., Oncogene 2000
(Melanoma) :
We recently demonstrated that through up-regulation of
TNFalpha ,
ATF2 increases the resistance of late stage melanoma cells to apoptosis induced by UV-irradiation
Valladares et al., Endocrinology 2000
:
In addition,
TNFalpha induced
activating transcription factor-1 phosphorylation is extensively decreased by SB203580
Miakotina et al., Am J Physiol Lung Cell Mol Physiol 2002
:
Finally,
TNF-alpha increased the phosphorylation of
ATF-2 , a transcription factor that is a p38 MAPK substrate
Kumawat et al., J Biol Chem 2010
(Acquired Immunodeficiency Syndrome...) :
Nef
inhibits ASK1/p38 MAPK dependent Mtb induced
TNF-alpha production probably by inhibiting binding of
ATF2 to the TNF-alpha promoter
Lee et al., J Nutr Biochem 2013
(Pneumonia) :
In addition, EGCG also attenuated
TNF-a induced oxidative stress, p47(phox) translocation, MAPKs activation, and STAT-3 and activating transcription factor
(ATF)2 phosphorylation
Tsai et al., Mol Cell Biol 1996
:
Tumor necrosis factor alpha gene regulation in activated T cells
involves ATF-2/Jun and NFATp ... This study is the first demonstration of a
role for
ATF-2 in
TNF-alpha gene transcription and of a functional interaction between ATF-2/Jun and NFATp
Tsai et al., Mol Cell Biol 1996
(Lymphoma) :
Cell-type-specific
regulation of the human
tumor necrosis factor alpha gene in B cells and T cells by NFATp and
ATF-2/JUN
Min et al., J Immunol 1997
:
In human endothelial cells,
TNF rapidly
induces N-terminal domain phosphorylation of both c-Jun and
ATF2