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ATP5O — GAST
Text-mined interactions from Literome
Yamamoto et al., Dig Dis Sci 1995
:
We examined the
effects of
gastrin and histamine on rat gastric H+/K ( + )
-ATPase , the enzyme responsible for H+ secretion, gene expression in vivo
Kaise et al., J Biol Chem 1995
:
On Northern blot analysis, both G-Gly and
gastrin dose-dependently
increased H+, K ( + )
-ATPase alpha-subunit gene expression with maximal induction ( 225 +/- 35 and 170 +/- 29 % of basal, mean +/- S.E. ) achieved at concentrations of 10 ( -9 ) M G-Gly and 10 ( -8 ) M gastrin, respectively ...
Gastrin peptides truncated at the carboxyl- ( G1-13 ) and amino terminus ( G5-17-Gly ) both
induced H+, K ( + )
-ATPase alpha-subunit gene expression and inhibited 125I-Leu15-G2-17-Gly binding, but were less potent than G2-17-Gly