◀ Back to REN

ATP5O — REN

Text-mined interactions from Literome

Schweda et al., American journal of physiology. Renal physiology 2000 : For this purpose we characterized the effects of the endoplasmatic Ca ( 2+ ) -ATPase inhibitors thapsigargin ( 300 nM ) and cyclopiazonic acid ( 20 microM ) on renin secretion from isolated perfused rat kidneys
Churchill et al., Life Sci 1990 : There is evidence that three inhibitors of Na, K-ATPase activity -- ouabain, K-free extracellular fluid, and vanadate -- inhibit renin secretion by increasing Ca2+ concentration in juxtaglomerular cells, but in the case of vanadate, it is uncertain whether the increase in Ca2+ is due to a decrease in Ca2+ efflux ( inhibition of Ca-ATPase activity, or inhibition of Na, K-ATPase activity, followed by an increase in intracellular Na+ and a decrease in Na-Ca exchange ) or to an increase in Ca2+ influx through potential operated Ca channels ( inhibition of electrogenic Na, K transport, followed by membrane depolarization and activation of Ca channels )
Cohen et al., Circ Res 1982 : The addition of ouabain to the perfusate containing 11 g per 100 ml inhibited the release of renin, suggesting that inhibition of Na-K-ATPase or the related changes in cellular volume or composition prevented renin release