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AXIN1 — LEF1

Text-mined interactions from Literome

Sakanaka et al., J Biol Chem 1999 (Colonic Neoplasms) : We also examined the ability of each Axin mutant to inhibit lymphoid enhancer factor-1 (Lef-1) reporter activity in a cell line expressing high levels of beta-catenin
Li et al., EMBO J 1999 : To understand the mechanism by which Dvl acts through GSK to regulate LEF-1, we investigated the roles of Axin and Frat1 in Wnt mediated activation of LEF-1 in mammalian cells
Mao et al., Mol Cell 2001 : In contrast, LRP-5 mutants lacking the extracellular domain functioned as constitutively active forms that bind Axin and that induce LEF-1 activation by destabilizing Axin and stabilizing beta-catenin
Li et al., J Biol Chem 2002 : We also showed that while both Axin and the DIX domain of Dishevelled ( Dvl ) could inhibit Dkk-2C2 induced activation of LEF-1 , the DEP domain of Dvl, which inhibited Wnt induced activation of LEF-1, failed to inhibit the activation of LEF-1 by Dkk-2C2 or by an activated form of LRP-5, LRPC2