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BAIAP2 — RAC3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Miki et al., Nature 2000
:
From studies of ectopic expression, we found that
IRSp53 is
essential for
Rac to induce membrane ruffling, probably because it recruits WAVE, which stimulates actin polymerization mediated by the Arp2/3 complex
Suetsugu et al., J Cell Biol 2006
:
Purified WAVE2 and purified WAVE2 complex were activated by
IRSp53 in a
Rac dependent manner with PIP ( 3 ) -containing liposomes
Abou-Kheir et al., J Cell Sci 2008
:
Membrane targeting of WAVE2 is not sufficient for WAVE2 dependent actin polymerization : a
role for
IRSp53 in mediating the interaction between
Rac and WAVE2
Teodorof et al., Exp Cell Res 2009
:
SPIN90 and
IRSp53 positively cooperated to
mediate Rac activation, and co-expression of SPIN90 and IRSp53 in COS-7 cells led to the complex formation of SPIN90-IRSp53 in the leading edge of cells