Gene interactions and pathways from curated databases and text-mining

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BRCA1 — IGF1

Text-mined interactions from Literome

Shukla et al., Cancer Res 2006 (Mammary Neoplasms, Experimental) : Furthermore, we provide evidence that activation of IGF signaling by BRCA1 deficiency can also occur in a p53 independent fashion
Maor et al., Horm Metab Res 2007 : Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1 ... Transient transfection experiments using BRCA1 promoter-luciferase reporter constructs reveal that IGF-I enhances BRCA1 promoter activity, suggesting that the effect of IGF-I is mediated at the transcriptional level
Maor et al., Cancer Lett 2007 (Breast Neoplasms) : To assess the potential inhibitory role of BRCA1 on IGF-IR levels, we infected the BRCA1-deficient HCC1937 cell line with a BRCA1 encoding adenoviral vector ... Results of Western blots showed that BRCA1 induced a large reduction in endogenous IGF-IR levels
Hudelist et al., Endocr Relat Cancer 2007 (Breast Neoplasms...) : siRNA mediated downregulation of BRCA1 in primary human mammary gland cells triggered upregulation of endogenous intracellular IGF-I in vitro
Schayek et al., Clin Cancer Res 2009 (Prostatic Neoplasms) : Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor ( IGF-IR ) gene transcription in an androgen receptor dependent manner ... On the other hand, BRCA1 enhanced IGF-IR levels in LNCaP C4-2 cells expressing an endogenous AR ... We provide evidence that BRCA1 differentially regulates IGF-IR expression in AR-positive and AR-negative prostate cancer cells
Kang et al., Cell death & disease 2012 (Breast Neoplasms) : BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site ... We report here that IGF-1 is negatively regulated by BRCA1 at the transcriptional level in human breast cancer cells ... Reporter analysis demonstrates that BRCA1 could regulate IGF-1 transcripts via this EREL site
Li et al., Frontiers in bioscience (Landmark edition) 2013 (Prostatic Neoplasms) : BRCA1 can directly interact with the androgen receptor (AR) and Janus kinase ( JAK ), and can differentially regulate insulin-like growth factor 1 receptor ( IGF-IR ) expression in an AR-dependent manner