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BRCA1 — IGF1
Text-mined interactions from Literome
Shukla et al., Cancer Res 2006
(Mammary Neoplasms, Experimental) :
Furthermore, we provide evidence that
activation of
IGF signaling by
BRCA1 deficiency can also occur in a p53 independent fashion
Maor et al., Horm Metab Res 2007
:
Insulin-like growth factor-I controls
BRCA1 gene expression through activation of transcription factor Sp1 ... Transient transfection experiments using BRCA1 promoter-luciferase reporter constructs reveal that
IGF-I enhances
BRCA1 promoter activity, suggesting that the effect of IGF-I is mediated at the transcriptional level
Maor et al., Cancer Lett 2007
(Breast Neoplasms) :
To assess the potential inhibitory
role of
BRCA1 on
IGF-IR levels, we infected the BRCA1-deficient HCC1937 cell line with a BRCA1 encoding adenoviral vector ... Results of Western blots showed that
BRCA1 induced a large reduction in endogenous
IGF-IR levels
Hudelist et al., Endocr Relat Cancer 2007
(Breast Neoplasms...) :
siRNA mediated downregulation of
BRCA1 in primary human mammary gland cells
triggered upregulation of endogenous intracellular
IGF-I in vitro
Schayek et al., Clin Cancer Res 2009
(Prostatic Neoplasms) :
Tumor suppressor
BRCA1 is expressed in prostate cancer and
controls insulin-like growth factor I receptor (
IGF-IR ) gene transcription in an androgen receptor dependent manner ... On the other hand,
BRCA1 enhanced
IGF-IR levels in LNCaP C4-2 cells expressing an endogenous AR ... We provide evidence that
BRCA1 differentially
regulates IGF-IR expression in AR-positive and AR-negative prostate cancer cells
Kang et al., Cell death & disease 2012
(Breast Neoplasms) :
BRCA1 negatively
regulates IGF-1 expression through an estrogen-responsive element-like site ... We report here that
IGF-1 is negatively
regulated by
BRCA1 at the transcriptional level in human breast cancer cells ... Reporter analysis demonstrates that
BRCA1 could
regulate IGF-1 transcripts via this EREL site
Li et al., Frontiers in bioscience (Landmark edition) 2013
(Prostatic Neoplasms) :
BRCA1 can directly interact with the androgen receptor (AR) and Janus kinase ( JAK ), and can differentially
regulate insulin-like growth factor 1 receptor (
IGF-IR ) expression in an AR-dependent manner